Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 2/20 | 0.48 |
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | STS | P08842 | 1/20 | 0.45 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7099621 | 0.79 | HDAC1 (0.42) | PDE4BPDE4APDE4CPDE4DSTS | |
| SCHEMBL25484153 | 0.79 | KDM4E (0.48) | PDE4BMEN1KMT2APDE4APDE4C | |
| SCHEMBL7147179 | 0.78 | PDE4B (0.55) | PDE4BMEN1KMT2APDE4APDE4C | |
| SCHEMBL19297154 | 0.77 | PDE4B (0.51) | PDE4BMEN1KMT2APDE4APDE4C | |
| SCHEMBL4854592 | 0.77 | MEN1 (0.64) | PDE4BMEN1KMT2AMAPTTP53 | |
| SCHEMBL25483959 | 0.76 | STS (0.50) | PDE4BMEN1KMT2APDE4APDE4C | |
| SCHEMBL31412656 | 0.76 | MMP13 (0.52) | PDE4BSLC6A4KDM4EMAPTTHRB | |
| SCHEMBL17080912 | 0.75 | GPR119 (0.46) | MEN1KMT2AKDM4EMAPTTHRB | |
| SCHEMBL4853312 | 0.75 | ALDH1A1 (0.54) | PDE4BMEN1KMT2APDE4APDE4C | |
| SCHEMBL17376154 | 0.75 | MEN1 (0.51) | PDE4BMEN1KMT2APDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030153764-A1 | Process for preparing 4-substituted piperidines | ELI LILLY AND COMPANY | 2003-08-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030153764-A1 | Process for preparing 4-substituted piperidines | PDGFRA, GTF3C5, GRIA4 | PDE4B 1031/4885HTR1A 316/4885SLC6A4 1890/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.