Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 10/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 8/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | CTSB | P07858 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL755311 | 0.98 | MAPT (0.39) | MAPTFAAHTRPV1ALDH1A1L3MBTL1 | |
| SCHEMBL755329 | 0.94 | FAAH (0.35) | MAPTFAAHTRPV1ALDH1A1L3MBTL1 | |
| SCHEMBL753927 | 0.89 | FFAR3 (0.35) | MAPTFAAHTRPV1NPSR1LPAR1 | |
| SCHEMBL11684551 | 0.82 | ALDH1A1 (0.41) | MAPTFAAHTRPV1ALDH1A1L3MBTL1 | |
| SCHEMBL11197381 | 0.82 | MAPT (0.40) | MAPTALDH1A1L3MBTL1NPSR1 | |
| SCHEMBL550992 | 0.81 | FAAH (0.39) | MAPTFAAHTRPV1CTSLCTSB | |
| SCHEMBL8981350 | 0.81 | FAAH (0.39) | MAPTFAAHTRPV1CTSLCTSB | |
| SCHEMBL1012064 | 0.81 | FAAH (0.39) | MAPTFAAHTRPV1CTSLCTSB | |
| SCHEMBL496169 | 0.81 | FAAH (0.39) | MAPTFAAHTRPV1CTSLCTSB | |
| SCHEMBL8980908 | 0.81 | FAAH (0.39) | MAPTFAAHTRPV1CTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1221535-C | Spiroimidazolidine derivatives, their preparation, their use and pharmaceutical preparations comprising them | AVENTIS PHARMA GMBH (DE) | 2005-10-05 | — | — | CN | disclosed |
| EP-1183241-B1 | SPIROIMIDAZOLIDINE DERIVATIVES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL PREPARATIONS COMPRISING THEM | AVENTIS PHARMA GMBH (DE) | 2003-09-17 | — | — | EP | disclosed |
| CN-1356986-A | Spiroimidazolidine derivatives, their prepn. their use and pharmaceutical prepns. comprising them | AVENTIS PHARMA GMBH (DE) | 2002-07-03 | — | — | CN | disclosed |
| US-6399643-B1 | ANTIINFLAMMATORY AGENTS; ANTIARTHRITIC AGENTS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-06-04 | — | — | US | disclosed |
| EP-1183241-A1 | SPIROIMIDAZOLIDINE DERIVATIVES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL PREPARATIONS COMPRISING THEM | Aventis Pharma Deutschland GmbH (DE) | 2002-03-06 | — | — | EP | disclosed |
| WO-2000069831-A1 | SPIROIMIDAZOLIDINE DERIVATIVES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL PREPARATIONS COMPRISING THEM | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-11-23 | — | — | WO | disclosed |