Sugi Predict

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SCHEMBL550992

SCHEMBL550992

CC(C)(C)OC(=O)NC1(C(=O)O)CCCCCCC1

nearest known ligand 0.39

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ FAAH O00519 9/20 0.39
▸ BTK Q06187 1/20 0.37
▸ GAA P10253 2/20 0.36
▸ MEN1 O00255 2/20 0.36
▸ KMT2A Q03164 2/20 0.36
▸ MAPK1 P28482 1/20 0.36
▸ EPHX1 P07099 1/20 0.36
▸ P2RX7 Q99572 1/20 0.35
▸ TRPV1 Q8NER1 6/20 0.35
▸ MAPT P10636 1/20 0.34
▸ CTSL P07711 1/20 0.34
▸ CTSB P07858 1/20 0.34
▸ CTSS P25774 1/20 0.34
▸ GHSR Q92847 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1012064 1.00 FAAH (0.39) FAAHBTKGAAMEN1KMT2A
SCHEMBL8981350 1.00 FAAH (0.39) FAAHBTKGAAMEN1KMT2A
SCHEMBL8980908 1.00 FAAH (0.39) FAAHBTKGAAMEN1KMT2A
SCHEMBL496169 1.00 FAAH (0.39) FAAHBTKGAAMEN1KMT2A
SCHEMBL76966 0.98 BTK (0.38) FAAHBTKGAAMEN1KMT2A
SCHEMBL202837 0.95 BTK (0.38) FAAHBTKGAAMEN1KMT2A
SCHEMBL142219 0.91 MEN1 (0.39) BTKGAAMEN1KMT2AMAPK1
SCHEMBL27646197 0.87 GAA (0.37) FAAHBTKGAAMEN1KMT2A
SCHEMBL15116645 0.86 GAA (0.36) FAAHBTKGAAMEN1KMT2A
SCHEMBL2789711 0.85 GHSR (0.37) FAAHBTKGAAMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 60 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11866422-B2 Carbocyclic prolinamide derivatives Orion Ophthalmology LLC (US) 2024-01-09 — — US disclosed
US-11267803-B2 Carbocyclic prolinamide derivatives Orion Ophthalmology LLC (US) 2022-03-08 — — US disclosed
US-20210347762-A1 CARBOCYCLIC PROLINAMIDE DERIVATIVES Orion Ophthalmology LLC (US) 2021-11-11 — — US disclosed
US-11091465-B2 — — 2021-08-17 — — US disclosed
US-20200385362-A1 CARBOCYCLIC PROLINAMIDE DERIVATIVES Orion Ophthalmology LLC (US) 2020-12-10 — — US disclosed
EP-3564240-A1 PIPERIDINE INTERMEDIATES Purdue Pharma L.P. (US) 2019-11-06 — — EP disclosed
EP-3564240-A1 PIPERIDINE INTERMEDIATES Purdue Pharma L.P. (US) 2019-11-06 — — EP disclosed
US-20190202810-A1 CARBOCYCLIC PROLINAMIDE DERIVATIVES Orion Ophthalmology LLC (US) 2019-07-04 — — US disclosed
EP-3472151-A1 CARBOCYCLIC PROLINAMIDE DERIVATIVES ORION OPTHALMOLOGY LLC (US) 2019-04-24 — — EP disclosed
WO-2017222914-A1 CARBOCYCLIC PROLINAMIDE DERIVATIVES INCEPTION 4, INC. (US) 2017-12-28 — — WO disclosed
US-20100216726-A1 Substituted-Quinoxaline-Type Piperidine Compounds and the Uses Thereof PURDUE PHARMA L.P. (US) 2010-08-26 — — US disclosed
US-20100216726-A1 Substituted-Quinoxaline-Type Piperidine Compounds and the Uses Thereof PURDUE PHARMA L.P. (US) 2010-08-26 — — US disclosed
US-20100022519-A1 HETEROCYCLIC-SUBSTITUTED PIPERIDINE COMPOUNDS AND THE USES THEREOF PURDUE PHARMA L.P. 2010-01-28 — — US disclosed
US-20100022519-A1 HETEROCYCLIC-SUBSTITUTED PIPERIDINE COMPOUNDS AND THE USES THEREOF PURDUE PHARMA L.P. 2010-01-28 — — US disclosed
CN-101595100-A Piperidines as the heterocyclic substituted of ORL-1 part PURDUE PHARMA LP (US) 2009-12-02 — — CN disclosed
EP-2076506-A2 HETEROCYCLIC-SUBSTITUTED PIPERIDINES AS ORL-1 LIGANDS Purdue Pharma L.P. (US) 2009-07-08 — — EP disclosed
WO-2009027820-A2 SUBSTITUTED-QUINOXALINE-TYPE-PIPERIDINE COMPOUNDS AND THE USES THEREOF PURDUE PHARMA L.P. (DE) 2009-03-05 — — WO disclosed
WO-2008089201-A2 HETEROCYCLIC-SUBSTITUTED PIPERIDINE AS ORL-1 LIGANDS PURDUE PHARMA L.P. (US) 2008-07-24 — — WO disclosed
WO-2008089201-A2 HETEROCYCLIC-SUBSTITUTED PIPERIDINE AS ORL-1 LIGANDS PURDUE PHARMA L.P. (US) 2008-07-24 — — WO disclosed
US-5543414-A VIRICIDES SYNTEX (USA) INC. (US) 1996-08-06 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190202810-A1 CARBOCYCLIC PROLINAMIDE DERIVATIVES HTRA1, ADCYAP1R1, HTRA2 FAAH 703/4885BTK 4274/4885GAA 2437/4885
US-20100216726-A1 Substituted-Quinoxaline-Type Piperidine Compounds and the Uses Thereof P2RX4, P2RX5, P2RX3 FAAH 371/4885BTK 2359/4885GAA 1694/4885
US-20100022519-A1 HETEROCYCLIC-SUBSTITUTED PIPERIDINE COMPOUNDS AND THE USES THEREOF TRPV1, P2RX4, TRPA1 FAAH 63/4885BTK 3475/4885GAA 2268/4885
US-11267803-B2 Carbocyclic prolinamide derivatives HTRA1, ADCYAP1R1, HTRA2 FAAH 703/4885BTK 4274/4885GAA 2437/4885
US-20200385362-A1 CARBOCYCLIC PROLINAMIDE DERIVATIVES HTRA1, ADCYAP1R1, HTRA2 FAAH 703/4885BTK 4274/4885GAA 2437/4885
US-11866422-B2 Carbocyclic prolinamide derivatives HTRA1, ADCYAP1R1, HTRA2 FAAH 703/4885BTK 4274/4885GAA 2437/4885
US-11091465-B2 — HTRA1, ALDH1A2, ADCYAP1R1 FAAH 860/4885BTK 4263/4885GAA 1699/4885
US-20210347762-A1 CARBOCYCLIC PROLINAMIDE DERIVATIVES HTRA1, ADCYAP1R1, HTRA2 FAAH 703/4885BTK 4274/4885GAA 2437/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.