Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.36 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL710081 | 0.84 | BCHE (0.68) | BCHENPC1RAB9AGAAPOLB | |
| SCHEMBL20677805 | 0.84 | BCHE (0.72) | BCHENPC1RAB9AGAAPOLB | |
| SCHEMBL20677810 | 0.77 | BCHE (0.77) | BCHENPC1RAB9AGAAPOLB | |
| SCHEMBL20677816 | 0.74 | BCHE (0.87) | BCHENPC1RAB9AGAAPOLB | |
| SCHEMBL20677807 | 0.74 | BCHE (0.87) | BCHENPC1RAB9AGAAPOLB | |
| SCHEMBL26459302 | 0.73 | BCHE (0.64) | BCHENPC1RAB9AGAASMN1; SMN2 | |
| SCHEMBL8201381 | 0.71 | BCHE (1.00) | BCHENPC1RAB9AGAAPOLB | |
| Hydrochloric Acid SCHEMBL710646 | 0.71 | BCHE (0.69) | BCHENPC1RAB9AGAAPOLB | |
| SCHEMBL7478941 | 0.70 | NPC1 (0.60) | NPC1RAB9AGAAPOLBEGLN3 | |
| SCHEMBL707879 | 0.70 | BCHE (0.73) | BCHENPC1RAB9AGAAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910426-B1 | DIENE POLYMERISATION | INEOS SALES (UK) LTD (GB) | 2018-01-03 | — | — | EP | disclosed |
| US-8124698-B2 | Diene polymerisation | INEOS EUROPE LIMITED (GB) | 2012-02-28 | — | — | US | disclosed |
| US-20100022724-A1 | Diene Polymerisation | INEOS SALES (UK) LIMITED (GB) | 2010-01-28 | — | — | US | disclosed |