Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.58 |
| ▸ | MEN1 | O00255 | 4/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 3/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7098427 | 0.88 | MEN1 (0.46) | KMT2AMEN1ALDH1A1POLB | |
| SCHEMBL7123940 | 0.76 | MEN1 (0.44) | KMT2AMEN1ALDH1A1POLB | |
| SCHEMBL7102400 | 0.69 | CA12 (0.54) | KMT2AMEN1KDM4EALDH1A1HPGD | |
| SCHEMBL7149800 | 0.68 | MEN1 (0.42) | KMT2AMEN1ALDH1A1POLB | |
| SCHEMBL6630982 | 0.67 | MEN1 (0.44) | KMT2AMEN1ALDH1A1POLB | |
| 7,8-Dihydrocalanolide B SCHEMBL29623986 | 0.65 | APAF1 (0.66) | KMT2AMEN1ALDH1A1POLB | |
| 7,8-Dihydrocalanolide B SCHEMBL29517130 | 0.65 | APAF1 (0.66) | KMT2AMEN1ALDH1A1POLB | |
| SCHEMBL31454911 | 0.64 | ALDH1A1 (0.54) | KMT2AGAAKDM4EALDH1A1CYP1A2 | |
| SCHEMBL17211707 | 0.64 | MEN1 (0.71) | KMT2AMEN1POLB | |
| SCHEMBL17211759 | 0.64 | MEN1 (0.73) | KMT2AMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6670383-B2 | Such as 5-(2-hydroxy-ethoxy)-2,2-dimethyl-6-propionyl-10-propyl-2H-pyrano(2,3 -f)chromen-8-one for treatment of Mycobacterium infection, AIDS, and tuburculosis | ADVANCED LIFE SCIENCES, INC. | 2003-12-30 | — | — | US | disclosed |
| US-20030083369-A1 | Pyranocoumarin compounds as a novel pharmacophore with anti-TB activity | THE LEADERS BANK | 2003-05-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030083369-A1 | Pyranocoumarin compounds as a novel pharmacophore with anti-TB activity | BBOX1, CYP51A1, HADHB | KMT2A 4419/4885MEN1 4150/4885GAA 956/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.