SCHEMBL7101251

SCHEMBL7101251

CC(=O)O[C@@H]1Cc2ccc([N+](=O)[O-])cc2[C@H]1N

nearest known ligand 0.43

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 0.43
CYP2C9 P11712 1/20 0.43
CYP2C19 P33261 1/20 0.43
CHRNB2 P17787 1/20 0.41
CHRNB4 P30926 1/20 0.41
CHRNA3 P32297 1/20 0.41
CHRNA4 P43681 1/20 0.41
PNMT P11086 6/20 0.39
ADRA2A P08913 4/20 0.39
ADRA2B P18089 3/20 0.39
ADRA2C P18825 3/20 0.39
KDM4E B2RXH2 1/20 0.38
MAPT P10636 1/20 0.38
SIRT2 Q8IXJ6 1/20 0.38
HSP90AA1 P07900 1/20 0.37
HIF1A Q16665 1/20 0.37
ALDH1A1 P00352 2/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7101254 1.00 CYP3A4 (0.43) CYP3A4CYP2C9CYP2C19CHRNB2CHRNB4
SCHEMBL12102700 0.80 CHRNB4 (0.41) CHRNB2CHRNB4CHRNA3CHRNA4PNMT
SCHEMBL2760596 0.79 LMNA (0.41) CYP2C9CHRNB2CHRNB4CHRNA3CHRNA4
SCHEMBL2760728 0.79 LMNA (0.41) CYP2C9CHRNB2CHRNB4CHRNA3CHRNA4
SCHEMBL2760727 0.79 LMNA (0.41) CYP2C9CHRNB2CHRNB4CHRNA3CHRNA4
SCHEMBL7149109 0.78 ALDH1A1 (0.41) CYP3A4CYP2C9CYP2C19CHRNB2CHRNB4
SCHEMBL7149107 0.78 ALDH1A1 (0.41) CYP3A4CYP2C9CYP2C19CHRNB2CHRNB4
SCHEMBL7109213 0.77 CYP3A4 (0.36) CYP3A4CYP2C9CYP2C19CHRNB2CHRNB4
SCHEMBL2760561 0.76 CHRNB4 (0.48) CHRNB2CHRNB4CHRNA3CHRNA4PNMT
SCHEMBL2760982 0.76 CHRNB4 (0.48) CHRNB2CHRNB4CHRNA3CHRNA4PNMT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0923543-B1 POTASSIUM CHANNEL INHIBITORS ICAGEN INC (US) 2003-09-24 EP disclosed
US-6083986-A Potassium channel inhibitors ICAGEN, INC. (US) 2000-07-04 US disclosed
EP-0923543-A1 POTASSIUM CHANNEL INHIBITORS Icagen, Inc. (US) 1999-06-23 EP disclosed
WO-1998004521-A1 POTASSIUM CHANNEL INHIBITORS ICAGEN, INC. (US) 1998-02-05 WO disclosed