Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | CNR1 | P21554 | 2/20 | 0.58 |
| ▸ | MMP8 | P22894 | 3/20 | 0.57 |
| ▸ | MLYCD | O95822 | 2/20 | 0.56 |
| ▸ | TACR1 | P25103 | 1/20 | 0.54 |
| ▸ | KDM4A | O75164 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | CNR2 | P34972 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL7103734 | 0.91 | MLYCD (0.54) | CYP2D6CYP2C9CYP2C19KMT2AMLYCD | |
| Trifluoroacetic Acid SCHEMBL7955825 | 0.87 | CYP2D6 (0.55) | CYP2D6CYP2C9CYP2C19KMT2ACNR1 | |
| Trifluoroacetic Acid SCHEMBL7101192 | 0.82 | MMP8 (0.53) | CYP2D6CYP2C9CYP2C19KMT2AMMP8 | |
| Trifluoroacetic Acid SCHEMBL27530667 | 0.81 | CYP2D6 (0.48) | CYP2D6CYP2C9CYP2C19KMT2ACNR1 | |
| Trifluoroacetic Acid SCHEMBL7067825 | 0.80 | MMP8 (0.54) | CYP2D6CYP2C9CYP2C19KMT2ACNR1 | |
| SCHEMBL10423181 | 0.79 | KMT2A (0.77) | CYP2D6CYP2C9CYP2C19KMT2ACNR1 | |
| SCHEMBL10611159 | 0.79 | KMT2A (0.77) | CYP2D6CYP2C9CYP2C19KMT2ACNR1 | |
| SCHEMBL10627851 | 0.79 | KMT2A (0.77) | CYP2D6CYP2C9CYP2C19KMT2ACNR1 | |
| SCHEMBL6155598 | 0.79 | POLB (0.71) | CYP2D6CYP2C9CYP2C19KMT2ACNR1 | |
| SCHEMBL13690869 | 0.78 | KMT2A (0.66) | CYP2D6CYP2C9CYP2C19KMT2ACNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140818-B1 | AMIDOMALONAMIDES AND THEIR USE AS INHIBITORS OF MATRIX METALLOPROTEINASE | AVENTIS PHARMA INC (US) | 2003-09-10 | — | — | EP | disclosed |
| US-6329550-B1 | FOR THERAPY OF EMPHYSEMA, OSTEOPOROSIS, RHEUMATOID ARTHRITIS AND NEOPLASTIC DISEASES | AVENTIS PHARMACEUTICALS INC. | 2001-12-11 | — | — | US | disclosed |
| EP-1140818-A1 | AMIDOMALONAMIDES AND THEIR USE AS INHIBITORS OF MATRIX METALLOPROTEINASE | Aventis Pharmaceuticals Inc. (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000040552-A1 | AMIDOMALONAMIDES AND THEIR USE AS INHIBITORS OF MATRIX METALLOPROTEINASE | AVENTIS PHARMACEUTICALS INC. (US) | 2000-07-13 | — | — | WO | disclosed |