Trifluoroacetic Acid

Trifluoroacetic Acid

SCHEMBL7101192

NC(C(=O)NCc1ccccc1)C(=O)NCc1ccccc1.O=C(O)C(F)(F)F

nearest known ligand 0.53

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MMP8 P22894 2/20 0.53
ALDH1A1 P00352 1/20 0.51
CYP3A4 P08684 1/20 0.51
F2 P00734 2/20 0.50
TMPRSS6 Q8IU80 2/20 0.50
OPRK1 P41145 1/20 0.50
TACR1 P25103 1/20 0.50
KIF11 P52732 1/20 0.49
MME P08473 1/20 0.49
KMT2A Q03164 1/20 0.49
HDAC3 O15379 1/20 0.48
HDAC4 P56524 1/20 0.48
HDAC1 Q13547 1/20 0.48
HDAC6 Q9UBN7 1/20 0.48
CYP1A2 P05177 1/20 0.47
CYP2D6 P10635 1/20 0.47
CYP2C9 P11712 1/20 0.47
TSHR P16473 1/20 0.47
CYP2C19 P33261 1/20 0.47
BACE1 P56817 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trifluoroacetic Acid SCHEMBL2396342 0.88 ALDH1A1 (0.56) MMP8ALDH1A1CYP3A4OPRK1MME
Trifluoroacetic Acid SCHEMBL10425462 0.85 ALDH1A1 (0.53) MMP8ALDH1A1CYP3A4F2TMPRSS6
Trifluoroacetic Acid SCHEMBL7103734 0.84 MLYCD (0.54) TACR1KMT2AHDAC3HDAC4HDAC1
Trifluoroacetic Acid SCHEMBL17106974 0.84 LAP3 (0.60) MMP8ALDH1A1CYP3A4F2TMPRSS6
Trifluoroacetic Acid SCHEMBL17106970 0.84 LAP3 (0.60) MMP8ALDH1A1CYP3A4F2TMPRSS6
Trifluoroacetic Acid SCHEMBL3587833 0.84 MMP2 (0.52) MMP8ALDH1A1CYP3A4F2TMPRSS6
Trifluoroacetic Acid SCHEMBL14762492 0.84 ALDH1A1 (0.56) MMP8ALDH1A1CYP3A4F2TMPRSS6
Trifluoroacetic Acid SCHEMBL7101439 0.82 CYP2D6 (0.60) MMP8TACR1KMT2ACYP2D6CYP2C9
Trifluoroacetic Acid SCHEMBL31151115 0.82 SLC1A1 (0.57) MMP8ALDH1A1CYP3A4OPRK1KMT2A
Trifluoroacetic Acid SCHEMBL10424902 0.81 SPHK1 (0.54) ALDH1A1CYP3A4OPRK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1140818-B1 AMIDOMALONAMIDES AND THEIR USE AS INHIBITORS OF MATRIX METALLOPROTEINASE AVENTIS PHARMA INC (US) 2003-09-10 EP disclosed
US-6329550-B1 FOR THERAPY OF EMPHYSEMA, OSTEOPOROSIS, RHEUMATOID ARTHRITIS AND NEOPLASTIC DISEASES AVENTIS PHARMACEUTICALS INC. 2001-12-11 US disclosed
EP-1140818-A1 AMIDOMALONAMIDES AND THEIR USE AS INHIBITORS OF MATRIX METALLOPROTEINASE Aventis Pharmaceuticals Inc. (US) 2001-10-10 EP disclosed
WO-2000040552-A1 AMIDOMALONAMIDES AND THEIR USE AS INHIBITORS OF MATRIX METALLOPROTEINASE AVENTIS PHARMACEUTICALS INC. (US) 2000-07-13 WO disclosed