Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | TNF | P01375 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.41 |
| ▸ | GRM3 | Q14832 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | LOX | P28300 | 1/20 | 0.41 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30661269 | 1.00 | DRD2 (0.48) | DRD2ALDH1A1GAAHSD17B10TSHR | |
| SCHEMBL5232319 | 0.85 | DRD2 (0.46) | DRD2ALDH1A1GAAHSD17B10ADRA1D | |
| SCHEMBL8233359 | 0.82 | ALDH1A1 (0.47) | DRD2ALDH1A1GAAHSD17B10NPC1 | |
| SCHEMBL7054313 | 0.82 | ALDH1A1 (0.47) | DRD2ALDH1A1GAAHSD17B10ADRA1D | |
| SCHEMBL1598016 | 0.82 | ALDH1A1 (0.48) | DRD2ALDH1A1HSD17B10TSHRNPC1 | |
| SCHEMBL25290560 | 0.81 | DRD2 (0.46) | DRD2ALDH1A1GAAHSD17B10ADRA1D | |
| SCHEMBL29593031 | 0.81 | DRD2 (0.46) | DRD2ALDH1A1GAAHSD17B10ADRA1D | |
| SCHEMBL21753331 | 0.80 | NR1H2 (0.51) | LOXL2NR1H2NR1H3 | |
| SCHEMBL1127911 | 0.80 | HTR6 (0.51) | DRD2ALDH1A1GAAHSD17B10GRM2 | |
| SCHEMBL4313800 | 0.80 | TSHR (0.52) | ALDH1A1HSD17B10TSHRNPC1TNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 86 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117043163-A | Pyrrolopyrimidine or pyrrolopyridine derivative and medical application thereof | 希格生科（深圳）有限公司 | 2023-11-10 | — | — | CN | disclosed |
| WO-2023036252-A1 | PYRROLOPYRIMIDINE OR PYRROLOPYRIDINE DERIVATIVE AND MEDICAL USE THEREOF | 希格生科（深圳）有限公司 | 2023-03-16 | — | — | WO | disclosed |
| US-11584755-B2 | Dihydrothieno[3,2-b]pyridine compounds | IDEAYA BIOSCIENCES, INC. (US) | 2023-02-21 | — | — | US | disclosed |
| CN-112028870-B | Compound with benzyloxy aromatic ring structure, preparation method and application thereof | 中国科学院上海药物研究所 | 2021-11-05 | — | — | CN | disclosed |
| WO-2020244518-A1 | COMPOUND WITH BENZYLOXY AROMATIC RING STRUCTURE, PREPARATION METHOD AND USE THEREOF | 中国科学院上海药物研究所 | 2020-12-10 | — | — | WO | disclosed |
| WO-2020244518-A1 | COMPOUND WITH BENZYLOXY AROMATIC RING STRUCTURE, PREPARATION METHOD AND USE THEREOF | 中国科学院上海药物研究所 | 2020-12-10 | — | — | WO | disclosed |
| CN-112028870-A | Compound with benzyloxy aromatic ring structure, preparation method and application thereof | 中国科学院上海药物研究所 | 2020-12-04 | — | — | CN | disclosed |
| CN-106536515-B | Compound as immunomodulator | 百时美施贵宝公司 | 2019-08-16 | — | — | CN | disclosed |
| WO-2019067442-A1 | DIHYDROTHIENO[3,2-b]PYRIDINE COMPOUNDS | IDEAYA BIOSCIENCES, INC. (US) | 2019-04-04 | — | — | WO | disclosed |
| EP-3131876-B1 | COMPOUNDS USEFUL AS IMMUNOMODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2018-11-07 | — | — | EP | disclosed |
| US-7067540-B2 | Substituted pyridinones | PHARMACIA CORPORATION (US) | 2006-06-27 | — | — | US | disclosed |
| US-20060079685-A1 | Aryl-quinazoline/aryl-2amino-phenyl methanone derivatives | NOVARTIS AG (CH) | 2006-04-13 | — | — | US | disclosed |
| EP-1585521-A2 | DERIVATIVES OF ARYL-QUINAZOLINE/ARYL-2AMINO-PHENYL METHANONE WHICH PROMOTE THE RELEASE OF PARATHYROID HORMONE | Novartis AG (CH) | 2005-10-19 | — | — | EP | disclosed |
| US-20050176775-A1 | Substituted pyridinones | PHARMACIA CORPORATION | 2005-08-11 | — | — | US | disclosed |
| CN-1646125-A | Substituted pyridones as modulators of P38MAP kinase | PHARMACIA CORP (US) | 2005-07-27 | — | — | CN | disclosed |
| WO-2005018557-A2 | SUBSTITUTED PYRIDINONES | PHARMACIA CORPORATION (US) | 2005-03-03 | — | — | WO | disclosed |
| EP-1490064-A1 | SUBSTITUTED PYRIDINONES AS MODULATORS OF P38 MAP KINASE | Pharmacia Corporation (US) | 2004-12-29 | — | — | EP | disclosed |
| WO-2004056365-A2 | DERIVATIVES OF ARYL-QUINAZOLINE/ARYL-2AMINO-PHENYL METHANONE WHICH PROMOTE THE RELEASE OF PARATHYROID HORMONE | NOVARTIS AG (CH) | 2004-07-08 | — | — | WO | disclosed |
| US-20040058964-A1 | Substituted pyridinones | PHARMACIA LLC | 2004-03-25 | — | — | US | disclosed |
| WO-2003068230-A1 | SUBSTITUTED PYRIDINONES AS MODULATORS OF P38 MAP KINASE | PHARMACIA CORPORATION (US) | 2003-08-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060079685-A1 | Aryl-quinazoline/aryl-2amino-phenyl methanone derivatives | PTH1R, PTMS, CYP24A1 | DRD2 2269/4885ALDH1A1 3159/4885GAA 1418/4885 |
| US-20040058964-A1 | Substituted pyridinones | MAPK1, MAPK6, MAPK7 | DRD2 2625/4885ALDH1A1 787/4885GAA 2281/4885 |
| US-11584755-B2 | Dihydrothieno[3,2-b]pyridine compounds | DHFR, CYC1, CYCS | DRD2 2560/4885ALDH1A1 700/4885GAA 2336/4885 |
| US-20050176775-A1 | Substituted pyridinones | MAPK1, MAPK6, MAP3K6 | DRD2 2177/4885ALDH1A1 741/4885GAA 2368/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.