Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4Z1 | Q86W10 | 2/20 | 0.48 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.46 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.46 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.46 |
| ▸ | CYP4F11 | Q9HBI6 | 1/20 | 0.43 |
| ▸ | CYP4F12 | Q9HCS2 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29702259 | 0.89 | CYP4F2 (0.56) | CYP4Z1CYP4F2CYP4A11SYKKDM4E | |
| SCHEMBL6307266 | 0.89 | CYP4F2 (0.56) | CYP4Z1CYP4F2CYP4A11SYKKDM4E | |
| SCHEMBL7099963 | 0.82 | CYP4F2 (0.46) | CYP4Z1CYP4F2CYP4A11TBXAS1CYP4F11 | |
| SCHEMBL9671800 | 0.81 | CYP4Z1 (0.65) | CYP4Z1CYP4F2CYP4A11TBXAS1CYP4F11 | |
| SCHEMBL6665672 | 0.81 | CYP4Z1 (0.50) | CYP4Z1CYP4F2CYP4A11TBXAS1CYP4F11 | |
| SCHEMBL5298324 | 0.80 | CYP4F2 (0.49) | CYP4Z1CYP4F2CYP4A11TBXAS1CYP4F11 | |
| SCHEMBL27956494 | 0.80 | JAK2 (0.45) | CYP4Z1TBXAS1KDM4EMEN1ALDH1A1 | |
| SCHEMBL29852292 | 0.80 | NFKB1 (0.65) | CYP4Z1CYP4F2CYP4A11TBXAS1CYP4F11 | |
| SCHEMBL3675681 | 0.79 | ALOX5 (0.57) | CYP4Z1CYP4F2CYP4A11CYP4F11CYP4F12 | |
| SCHEMBL19236921 | 0.78 | CASP3 (0.57) | TBXAS1PPARGPPARATDP1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1229910-A4 | INTEGRIN RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2003-10-01 | — | — | EP | disclosed |
| EP-1229910-A1 | INTEGRIN RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2002-08-14 | — | — | EP | disclosed |
| US-6413955-B1 | 1,8-NAPHTHYRIDINES OR 5-THIO-1,8-NAPHTHYRIDINES OR 5-OXO-1,8-NAPHTHYRIDINES; BONE RESORPTION, OSTEOPOROSIS, VASCULAR REST-ENOSIS, DIABETIC RETINOPATHY, MACULAR DEGENERATION, ANGIO-GENESIS, ATHEROSCLEROSIS, INFLAMMATORY ARTHRITIS, CANCER | MERCK & CO., INC. | 2002-07-02 | — | — | US | disclosed |
| WO-2001024797-A1 | INTEGRIN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2001-04-12 | — | — | WO | disclosed |