Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGA4 | P13612 | 12/20 | 0.45 |
| ▸ | ITGB1 | P05556 | 4/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 6/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | BCL2 | P10415 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16232045 | 0.80 | ATM (0.62) | ATM | |
| SCHEMBL4417313 | 0.80 | ITGA4 (0.62) | ITGA4ITGB1PTPN1 | |
| SCHEMBL1309887 | 0.80 | ITGA4 (0.62) | ITGA4ITGB1PTPN1 | |
| SCHEMBL838170 | 0.80 | ITGA4 (0.62) | ITGA4ITGB1PTPN1 | |
| SCHEMBL10883351 | 0.79 | ITGA4 (0.52) | ITGA4ITGB1PTPN1BCL2 | |
| SCHEMBL2779890 | 0.79 | MMEL1 (0.62) | — | |
| SCHEMBL2779899 | 0.79 | MMEL1 (0.62) | — | |
| SCHEMBL1912622 | 0.79 | CTSS (0.55) | ATMBCL2 | |
| SCHEMBL1912621 | 0.79 | CTSS (0.55) | ATMBCL2 | |
| SCHEMBL7098063 | 0.79 | ITGA4 (0.48) | ITGA4ITGB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0991619-B1 | INHIBITORS OF ALPHA 4-BETA 1 MEDIATED CELL ADHESION | TANABE SEIYAKU CO (JP) | 2003-09-10 | — | — | EP | disclosed |
| US-6596752-B1 | Small molecules that are potent inhibitors of alpha 4 beta 1 mediated adhesion to either VCAM or CS-1 and which could be useful for the treatment of inflammatory diseases. | TANABE SEIYAKU CO., LTD. (JP) | 2003-07-22 | — | — | US | disclosed |
| US-6482849-B1 | Inhibitors of α4β1 mediated cell adhesion | TANABE SEIYAKU CO., LTD. (JP) | 2002-11-19 | — | — | US | disclosed |
| EP-0991619-A1 | INHIBITORS OF $g(a) 4?$g(b) 1?MEDIATED CELL ADHESION | TANABE SEIYAKU CO., LTD. (JP) | 2000-04-12 | — | — | EP | disclosed |
| WO-1998058902-A1 | INHIBITORS OF α4β1MEDIATED CELL ADHESION | TANABE SEIYAKU CO., LTD. (JP) | 1998-12-30 | — | — | WO | disclosed |