SCHEMBL838170

SCHEMBL838170

CC(C)(C)OC(=O)NC(Cc1ccc(OCc2c(Cl)cccc2Cl)cc1)C(=O)O

nearest known ligand 0.62

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
ITGA4 P13612 16/20 0.62
ITGB3 P05106 1/20 0.61
ITGA2B P08514 1/20 0.61
PTPN1 P18031 3/20 0.60
ITGB1 P05556 4/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4417313 1.00 ITGA4 (0.62) ITGA4ITGB3ITGA2BPTPN1ITGB1
SCHEMBL1309887 1.00 ITGA4 (0.62) ITGA4ITGB3ITGA2BPTPN1ITGB1
SCHEMBL10883351 0.91 ITGA4 (0.52) ITGA4ITGB3ITGA2BPTPN1ITGB1
SCHEMBL6129624 0.89 PTPN1 (0.61) ITGA4ITGB3ITGA2BPTPN1ITGB1
SCHEMBL6129676 0.89 PTPN1 (0.61) ITGA4ITGB3ITGA2BPTPN1ITGB1
SCHEMBL7340367 0.89 ITGA4 (0.57) ITGA4ITGB3ITGA2BPTPN1ITGB1
SCHEMBL7340357 0.89 ITGA4 (0.57) ITGA4ITGB3ITGA2BPTPN1ITGB1
SCHEMBL8925517 0.88 PTPN1 (0.66) ITGA4ITGB3ITGA2BPTPN1
SCHEMBL193474 0.85 PTPN1 (0.73) ITGB3ITGA2BPTPN1
SCHEMBL193473 0.85 PTPN1 (0.73) ITGB3ITGA2BPTPN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9115169-B2 Method of treating tumors LYTIX BIOPHARMA AS (NO) 2015-08-25 US disclosed
US-9109048-B2 Inhibition of tumor growth LYTIX BIOPHARMA AS (NO) 2015-08-18 US disclosed
US-20140037657-A1 INHIBITION OF TUMOR GROWTH LYTIX BIOPHARMA AS (NO) 2014-02-06 US disclosed
US-8283315-B2 Inhibition of tumour growth LYTIX BIOPHARMA AS (NO) 2012-10-09 US disclosed
US-20120108520-A1 Antimicrobial Compounds and Formulations LYTIX BIOPHARMA AS (NO) 2012-05-03 US disclosed
US-8143211-B2 Bioactive peptides LYTIX BIOPHARMA AS (NO) 2012-03-27 US disclosed
US-8048852-B2 Antimicrobial compounds and formulations LYTIX BIOPHARMA AS (NO) 2011-11-01 US disclosed
EP-1263471-B1 ANTIMICROBIAL COMPOUNDS AND FORMULATIONS LYTIX BIOPHARMA AS (NO) 2011-10-12 EP disclosed
EP-2338522-A1 Antitumoural therapies Lytix Biopharma AS (NO) 2011-06-29 EP disclosed
EP-1109831-B1 CYCTOTOXIC PEPTIDES MODIFIED BY BULKY OR LIPOPHILIC MOIETIES LYTIX BIOPHARMA AS (NO) 2011-01-12 EP disclosed
US-7232803-B2 Antimicrobial compounds and formulations LYTIX BIOPHARMA AS (NO) 2007-06-19 US disclosed
US-6890902-B2 Cytotoxic modified lactoferrin peptides ALPHARMA AS (NO) 2005-05-10 US disclosed
US-20030195144-A1 Antimicrobial compounds and formulations LYTIX BIOPHARMA AS (NO) 2003-10-16 US disclosed
US-20030148936-A1 Bioactive peptides ALPHARMA AS. 2003-08-07 US disclosed
US-20030022821-A1 Bioactive peptides ALPHARMA AS 2003-01-30 US disclosed
EP-1263471-A2 ANTIMICROBIAL COMPOUNDS AND FORMULATIONS ALPHARMA AS (NO) 2002-12-11 EP disclosed
WO-2001066147-A2 ANTIMICROBIAL COMPOUNDS AND FORMULATIONS ALPHARMA AS (NO) 2001-09-13 WO disclosed
EP-1109831-A2 CYCTOTOXIC PEPTIDES MODIFIED BY BULKY OR LIPOPHILIC MOIETIES ALPHARMA AS (NO) 2001-06-27 EP disclosed
WO-2000012541-A2 CYTOTOXIC PEPTIDES MODIFIED BY BULKY OR LIPOPHILIC MOIETIES ALPHARMA AS (NO) 2000-03-09 WO disclosed
US-4534897-A Piperazinone, piperazine, 1,4-diazepin-2-one and 1,4-diazepine intermediate compounds THE UPJOHN COMPANY (US) 1985-08-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120108520-A1 Antimicrobial Compounds and Formulations VIP, NONO, CLPTM1 ITGA4 2575/4885ITGB3 1781/4885ITGA2B 3032/4885
US-20030148936-A1 Bioactive peptides VIP, NGLY1, HM13 ITGA4 4539/4885ITGB3 3804/4885ITGA2B 4354/4885
US-20030195144-A1 Antimicrobial compounds and formulations LPO, CLPTM1, VIP ITGA4 3284/4885ITGB3 2378/4885ITGA2B 3075/4885
US-20030022821-A1 Bioactive peptides VIP, LITAF, LNPEP ITGA4 3238/4885ITGB3 2610/4885ITGA2B 3218/4885
US-20140037657-A1 INHIBITION OF TUMOR GROWTH STING1, VIP, MIF ITGA4 3403/4885ITGB3 3720/4885ITGA2B 3917/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.