Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 6/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | FDPS | P14324 | 1/20 | 0.35 |
| ▸ | DEPTOR | Q8TB45 | 1/20 | 0.34 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.34 |
| ▸ | FADS1 | O60427 | 1/20 | 0.34 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27675521 | 0.79 | MAPT (0.50) | GAAALDH1A1MAPTLMNAMEN1 | |
| SCHEMBL28730319 | 0.77 | HCAR2 (0.37) | ALDH1A1MAPTLMNAMEN1KMT2A | |
| SCHEMBL1758240 | 0.76 | PTGS2 (0.45) | GAAALDH1A1MAPTLMNAALOX12 | |
| SCHEMBL4858206 | 0.76 | TSHR (0.57) | GAAALDH1A1MAPTLMNAALOX12 | |
| SCHEMBL2074386 | 0.75 | ALDH1A1 (0.44) | GAAALDH1A1MAPTLMNAALOX12 | |
| SCHEMBL28183482 | 0.71 | RAPGEF4 (0.38) | GAAMAPTLMNAMEN1KMT2A | |
| SCHEMBL7151208 | 0.71 | MEN1 (0.53) | ALDH1A1MAPTLMNAMEN1KMT2A | |
| SCHEMBL6755623 | 0.70 | ALDH1A1 (0.44) | ALDH1A1MAPTLMNATSHRMEN1 | |
| 1,3,5-Trichlorobenzene SCHEMBL27925487 | 0.69 | TSHR (0.47) | GAAALDH1A1MAPTLMNAALOX12 | |
| SCHEMBL12838310 | 0.69 | GAA (0.48) | GAAALDH1A1MAPTLMNAALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1339668-A2 | BISUBSTITUTED CARBOCYCLIC CYCLOPHILIN BINDING COMPOUNDS AND THEIRUS | GUILFORD PHARMACEUTICALS INC. (US) | 2003-09-03 | — | — | EP | claimed |
| WO-2002044126-A2 | BISUBSTITUTED CARBOCYCLIC CYCLOPHILIN BINDING COMPOUNDS AND THEIRUS | GUILFORD PHARMACEUTICALS INC. (US) | 2002-06-06 | — | — | WO | claimed |