SCHEMBL1758240

SCHEMBL1758240

O=CNNc1ccc(Cl)cc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 4/20 0.45
HSD17B10 Q99714 1/20 0.42
NPC1 O15118 2/20 0.40
CA1 P00915 1/20 0.40
CA2 P00918 1/20 0.40
ALDH1A1 P00352 7/20 0.40
SMN1; SMN2 Q16637 3/20 0.40
GAA P10253 6/20 0.39
RAB9A P51151 2/20 0.39
CYP1A2 P05177 1/20 0.39
CYP3A4 P08684 1/20 0.39
ALOX12 P18054 1/20 0.39
CYP2C19 P33261 1/20 0.39
CES1 P23141 1/20 0.39
HTT P42858 2/20 0.38
LMNA P02545 2/20 0.38
CYP2A6 P11509 1/20 0.38
MAPT P10636 2/20 0.37
TDP1 Q9NUW8 2/20 0.37
AGTR1 P30556 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9785803 0.87 MEN1 (0.56) NPC1CA1CA2ALDH1A1SMN1; SMN2
SCHEMBL9644441 0.81 ALDH1A1 (0.31) ALDH1A1
SCHEMBL7102678 0.76 GAA (0.42) ALDH1A1GAARAB9AALOX12LMNA
SCHEMBL6673208 0.76 TDP1 (0.45) PTGS2NPC1CA1CA2ALDH1A1
SCHEMBL8989664 0.76 ALDH5A1 (0.42) HSD17B10NPC1CA1CA2ALDH1A1
SCHEMBL6671214 0.76 TGM2 (0.41) NPC1ALDH1A1GAARAB9ACYP1A2
SCHEMBL6727924 0.76 MAPT (0.43) HSD17B10CA1CA2ALDH1A1SMN1; SMN2
SCHEMBL2383778 0.76 IDO1 (0.45) NPC1CA1CA2ALDH1A1SMN1; SMN2
SCHEMBL3260825 0.76 LMNA (0.57) PTGS2NPC1CA1CA2ALDH1A1
SCHEMBL243768 0.75 ALDH1A1 (0.56) PTGS2HSD17B10ALDH1A1SMN1; SMN2GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011051958-A1 FUNGICIDAL PYRAZOLONES E.I. DU PONT DE NEMOURS AND COMPANY (US) 2011-05-05 WO disclosed
EP-1057076-B1 HIGH CONTRAST PHOTOGRAPHIC SILVER HALIDE MATERIAL EASTMAN KODAK CO (US) 2004-09-29 EP disclosed
US-6383711-B1 PHOTOGRAPHIC FILMS WITH SUPPORTS AND SILVER HALIDE EMULSIONS AND HYDROPHILIC COLLOIDS EASTMAN KODAK COMPANY 2002-05-07 US disclosed
EP-0682288-B1 High contrast photographic silver halide material EASTMAN KODAK CO (US) 2001-06-27 EP disclosed
EP-0681208-B1 High contrast photographic silver halide material EASTMAN KODAK CO (US) 2001-05-16 EP disclosed
EP-0650086-B1 Method of improving abrasion resistance of photographic silver halide materials KODAK LTD (GB) 1999-12-08 EP disclosed
EP-0774686-B1 High-contrast photographic elements protected against halation EASTMAN KODAK CO (US) 1999-07-21 EP disclosed
EP-0609947-B1 High-contrast photographic elements with improved print-out capability EASTMAN KODAK CO (US) 1999-05-12 EP disclosed
EP-0574078-B1 Photographic high contrast silver halide materials KODAK LTD (GB) 1998-11-25 EP disclosed
EP-0735415-B1 Photographic elements with tetra-nuclear merocyanine sensitizers EASTMAN KODAK CO (US) 1998-09-16 EP disclosed
US-5298362-A Graphic arts for images, supports with colloid layers for photography with hydrazine nucleating agents EASTMAN KODAK COMPANY (US) 1994-03-29 US disclosed
EP-0574078-A2 Photographic high contrast silver halide materials KODAK LIMITED (GB) 1993-12-15 EP disclosed
EP-0536345-A1 PHOTOGRAPHIC HIGH CONTRAST SILVER HALIDE MATERIALS KODAK LIMITED (GB) 1993-04-14 EP disclosed
WO-1992015042-A1 PHOTOGRAPHIC HIGH CONTRAST SILVER HALIDE MATERIALS KODAK LIMITED (GB) 1992-09-03 WO disclosed
EP-0267264-B1 HIGH CONTRAST DEVELOPMENT OF PHOTOGRAPHIC ELEMENTS EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1990-07-25 EP disclosed
EP-0301946-A1 Process for the preparation of 1,2,4-triazol-3-ones SOCIETE NATIONALE DES POUDRES ET EXPLOSIFS (FR) 1989-02-01 EP disclosed
EP-0226184-A2 Nucleation development control agent for photographic silver halide materials and processes EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1987-06-24 EP disclosed
US-4650746-A HYDRAZIDE NUCLEATING AGENTS EASTMAN KODAK COMPANY (US) 1987-03-17 US disclosed
EP-0032456-B1 METHOD FOR HIGH CONTRAST DEVELOPMENT OF PHOTOGRAPHIC ELEMENTS EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1983-02-02 EP disclosed
EP-0032456-A1 Method for high contrast development of photographic elements EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1981-07-22 EP disclosed