SCHEMBL7102932

SCHEMBL7102932

O=C(NC(=O)c1ccccc1)Nc1cccc(-c2ccc(C(F)(F)F)cn2)c1

nearest known ligand 0.52

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 3/20 0.52
NPC1 O15118 2/20 0.52
MAPT P10636 3/20 0.51
MAPK1 P28482 1/20 0.51
KMT2A Q03164 3/20 0.50
MEN1 O00255 2/20 0.50
KCNK3 O14649 1/20 0.50
RIPK1 Q13546 2/20 0.48
PTGES O14684 1/20 0.48
HTT P42858 2/20 0.48
EPHX2 P34913 1/20 0.47
LMNA P02545 1/20 0.46
CCR2 P41597 1/20 0.46
RXFP1 Q9HBX9 1/20 0.46
IGF1R P08069 1/20 0.46
TRPV1 Q8NER1 1/20 0.46
CNR1 P21554 1/20 0.46
L3MBTL1 Q9Y468 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10416275 0.83 RAB9A (0.50) RAB9ANPC1MAPTKMT2AMEN1
SCHEMBL11440381 0.81 MAPT (0.73) RAB9ANPC1MAPTKMT2AMEN1
SCHEMBL10769853 0.80 GAA (0.69) RAB9ANPC1MAPTMAPK1LMNA
SCHEMBL29994366 0.79 MRGPRX4 (0.57) RAB9ANPC1KMT2AMEN1
SCHEMBL4114114 0.79 MAPT (0.67) RAB9ANPC1MAPTKMT2AMEN1
SCHEMBL10340655 0.77 RAB9A (0.48) RAB9ANPC1MAPTKMT2AMEN1
SCHEMBL11203659 0.74 RAB9A (0.56) RAB9AMAPTKMT2AMEN1HTT
SCHEMBL1335468 0.72 SIRT1 (0.81) RAB9ANPC1MAPTKMT2AMEN1
SCHEMBL1038443 0.72 SMN1; SMN2 (0.57) RAB9ANPC1MAPTHTTLMNA
SCHEMBL5934468 0.72 TRPV1 (0.71) RAB9ANPC1TRPV1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0917822-B1 Method to control animal ecto-parasites SUMITOMO CHEMICAL CO (JP) 2003-10-08 EP disclosed
US-6333355-B2 1-(2,6-DIFLUOROBENZOYL)-3-(2-FLUORO-4-(1,1,2,3,3,3 -HEXAFLUOROP ROPOXY)PHENYL)UREA; FLEAS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2001-12-25 US disclosed
US-20010044470-A1 METHOD TO CONTROL ANIMAL ECTO-PARASITES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2001-11-22 US disclosed
EP-0917822-A1 Method to control animal ecto-parasites SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1999-05-26 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20010044470-A1 METHOD TO CONTROL ANIMAL ECTO-PARASITES ENPP3, ENPP1, TUBA3C RAB9A 1283/4885NPC1 3371/4885MAPT 4466/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.