Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.36 |
| ▸ | CDK2 | P24941 | 5/20 | 0.36 |
| ▸ | TTK | P33981 | 5/20 | 0.36 |
| ▸ | AURKA | O14965 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 2/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6494995 | 0.79 | KDM4E (0.38) | KDM4ENPC1RAB9AMAPTCASP3 | |
| SCHEMBL7019407 | 0.77 | CCNB2 (0.38) | KDM4ENPC1RAB9AMAPTCASP3 | |
| SCHEMBL7019826 | 0.77 | RIPK1 (0.42) | KDM4ENPC1RAB9AMAPTCASP3 | |
| SCHEMBL7019380 | 0.76 | RIPK1 (0.41) | CCNA2CDK2TTKAURKACCNB2 | |
| SCHEMBL7016752 | 0.76 | EGFR (0.35) | KDM4ENPC1RAB9AMAPTCASP3 | |
| SCHEMBL6286924 | 0.71 | CYP1A1 (0.44) | KDM4ENPC1RAB9AMAPTCASP3 | |
| SCHEMBL7104266 | 0.68 | PDGFRB (0.38) | KDM4EMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL6286918 | 0.67 | PARP1 (0.47) | CCNA2CDK2TTKAURKAFYN | |
| SCHEMBL7100815 | 0.64 | RIPK1 (0.42) | KDM4ENPC1RAB9AMAPTCASP3 | |
| SCHEMBL4820299 | 0.62 | ESR2 (0.48) | KDM4ENPC1RAB9AMAPTCASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1294718-A2 | 6,5-FUSED BICYCLIC HETEROCYCLES | WARNER-LAMBERT COMPANY LLC (US) | 2003-03-26 | — | — | EP | disclosed |
| WO-2001096336-A2 | 6,5-FUSED BICYCLIC HETEROCYCLES | WARNER-LAMBERT COMPANY (US) | 2001-12-20 | — | — | WO | disclosed |