Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 6/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | SLC9A1 | P19634 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CTSB | P07858 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5120287 | 0.92 | TDP1 (0.46) | TDP1TSHRMAPTRAB9AHPGD | |
| SCHEMBL5120258 | 0.84 | GPR3 (0.46) | TDP1TSHRMAPTRAB9AHPGD | |
| SCHEMBL17952462 | 0.77 | MAPT (0.42) | TDP1MAPTRAB9AHPGDNPC1 | |
| SCHEMBL31677913 | 0.76 | LMNA (0.43) | TDP1TSHRMAPTHPGDCYP3A4 | |
| SCHEMBL16919342 | 0.75 | CTSB (0.40) | TDP1TSHRMAPTRAB9AHPGD | |
| SCHEMBL3293386 | 0.74 | TDP1 (0.53) | TDP1MAPTCYP3A4SLC9A1ALDH1A1 | |
| SCHEMBL31478092 | 0.74 | TDP1 (0.53) | TDP1MAPTCYP3A4SLC9A1ALDH1A1 | |
| SCHEMBL16919393 | 0.71 | KMT2A (0.43) | TDP1MAPTRAB9AHPGDNPC1 | |
| SCHEMBL1683191 | 0.71 | TSHR (0.57) | TDP1TSHRMAPTCYP3A4SMN1; SMN2 | |
| SCHEMBL16218709 | 0.69 | TDP1 (0.47) | TDP1MAPTRAB9ANPC1SLC9A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1278739-A1 | AMINO SUBSTITUTED DIBENZOTHIOPHENE DERIVATIVES FOR THE TREATMENT OF DISORDERS MEDIATED BY THE NP Y5 RECEPTOR | AstraZeneca AB (SE) | 2003-01-29 | — | — | EP | disclosed |
| WO-2001085714-A1 | AMINO SUBSTITUTED DIBENZOTHIOPHENE DERIVATIVES FOR THE TREATMENT OF DISORDERS MEDIATED BY THE NP Y5 RECEPTOR | ASTRAZENECA AB (SE) | 2001-11-15 | — | — | WO | disclosed |