Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | ALPL | P05186 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 3/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.30 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.30 |
| ▸ | LOX | P28300 | 1/20 | 0.30 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12678022 | 0.82 | SPR (0.39) | L3MBTL1CA2 | |
| SCHEMBL7107359 | 0.81 | HDAC4 (0.39) | POLB | |
| SCHEMBL7656985 | 0.80 | L3MBTL1 (0.53) | L3MBTL1ALPLPOLBGAAMAPT | |
| SCHEMBL18131023 | 0.79 | KDM4E (0.50) | POLB | |
| SCHEMBL7105124 | 0.79 | L3MBTL1 (0.41) | L3MBTL1CA2ALPLPOLBMAPT | |
| SCHEMBL7650135 | 0.76 | NTRK2 (0.44) | L3MBTL1CA2ALPLPOLBNTRK2 | |
| SCHEMBL7108508 | 0.76 | — | — | |
| SCHEMBL7107198 | 0.74 | — | — | |
| SCHEMBL8052564 | 0.71 | POLB (0.36) | L3MBTL1CA2ALPLPOLBNTRK2 | |
| SCHEMBL7103619 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001944-B1 | PYRAZINE DERIVATIVES, PREPARATION AND MEDICINES CONTAINING THEM | AVENTIS PHARMA SA (FR) | 2003-10-01 | — | — | EP | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | disclosed |