Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | ALPL | P05186 | 1/20 | 0.35 |
| ▸ | KDM4A | O75164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2778476 | 0.82 | TDP1 (0.43) | L3MBTL1KDM4EALOX15TSHRACMSD | |
| SCHEMBL7652649 | 0.81 | HTR2C (0.46) | L3MBTL1KDM4EALOX15TSHRACMSD | |
| SCHEMBL7103529 | 0.80 | L3MBTL1 (0.42) | L3MBTL1POLBGAAMAPTALPL | |
| SCHEMBL2401264 | 0.79 | ADRA2C (0.42) | L3MBTL1KDM4EALOX15TSHRACMSD | |
| SCHEMBL3677823 | 0.79 | CES2 (0.52) | L3MBTL1KDM4EALOX15LMNAKMT2A | |
| SCHEMBL12487684 | 0.79 | ALDH1A1 (0.48) | KDM4ELMNATP53GAA | |
| SCHEMBL15898875 | 0.78 | L3MBTL1 (0.69) | L3MBTL1TSHRTDP1MEN1KMT2A | |
| SCHEMBL12487467 | 0.78 | ALDH1A1 (0.50) | L3MBTL1KDM4EALOX15TSHRACMSD | |
| SCHEMBL28817951 | 0.77 | PIM1 (0.39) | L3MBTL1KDM4EALOX15TSHRACMSD | |
| SCHEMBL7651870 | 0.76 | TDP1 (0.41) | L3MBTL1KDM4EALOX15TSHRACMSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | disclosed |