Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7104725 | 0.87 | ADAM17 (0.39) | — | |
| Hydrochloric Acid SCHEMBL7104764 | 0.86 | ADAM17 (0.39) | — | |
| SCHEMBL6942423 | 0.81 | TGFBR1 (0.33) | TGFBR1 | |
| SCHEMBL8097973 | 0.80 | P2RX3 (0.32) | TGFBR1 | |
| SCHEMBL6945779 | 0.78 | TGFBR1 (0.33) | TGFBR1 | |
| SCHEMBL6944946 | 0.76 | TGFBR1 (0.32) | TGFBR1 | |
| SCHEMBL6943244 | 0.76 | TGFBR1 (0.35) | TGFBR1 | |
| SCHEMBL6946755 | 0.76 | TGFBR1 (0.32) | TGFBR1 | |
| SCHEMBL6944954 | 0.75 | ADAM17 (0.37) | — | |
| SCHEMBL6983333 | 0.75 | TGFBR1 (0.33) | TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1133471-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-09-17 | — | — | EP | disclosed |
| EP-1133471-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-09-19 | — | — | EP | disclosed |
| US-6265446-B1 | ANTIINFLAMMATORY AGENTS; AUTOIMMUNE DISEASES | HOFFMANN-LA ROCHE INC.. | 2001-07-24 | — | — | US | disclosed |
| WO-2000032570-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-06-08 | — | — | WO | disclosed |