Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.44 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.44 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | KIF11 | P52732 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | ALPG | P10696 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7103759 | 1.00 | LMNA (0.45) | LMNAHPGDSMN1; SMN2USP2ALDH1A1 | |
| SCHEMBL4799034 | 0.94 | SLC1A1 (0.47) | LMNASLC1A3SLC1A2SLC1A1CYP2D6 | |
| SCHEMBL3164836 | 0.94 | SLC1A1 (0.47) | LMNASLC1A3SLC1A2SLC1A1CYP2D6 | |
| Hydrochloric Acid SCHEMBL4798059 | 0.92 | SLC1A1 (0.46) | LMNASLC1A3SLC1A2SLC1A1CYP2D6 | |
| SCHEMBL19696802 | 0.89 | SLC1A1 (0.49) | SLC1A1EPHX1CNR2 | |
| SCHEMBL43672 | 0.88 | DPP4 (0.52) | LMNASLC1A3SLC1A2SLC1A1CYP2D6 | |
| SCHEMBL43670 | 0.88 | DPP4 (0.52) | LMNASLC1A3SLC1A2SLC1A1CYP2D6 | |
| SCHEMBL502830 | 0.88 | DPP4 (0.52) | LMNASLC1A3SLC1A2SLC1A1CYP2D6 | |
| Hydrochloric Acid SCHEMBL4799572 | 0.86 | DPP4 (0.50) | LMNAALDH1A1SLC1A3SLC1A2SLC1A1 | |
| Hydrochloric Acid SCHEMBL9445669 | 0.86 | DPP4 (0.50) | LMNAALDH1A1SLC1A3SLC1A2SLC1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6649613-B1 | Integrin inhibitors | MERCK PATENT GMBH (DE) | 2003-11-18 | — | — | US | disclosed |
| EP-1194401-B1 | DIACYLHYDRAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2003-09-10 | — | — | EP | disclosed |