SCHEMBL7103956

SCHEMBL7103956

CNN1CCCC1c1cncc(C(F)(F)F)c1

nearest known ligand 0.47

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CHRNB4 P30926 5/20 0.39
CHRNA3 P32297 5/20 0.39
CHRNB2 P17787 4/20 0.39
CHRNA1 P02708 3/20 0.39
CHRNB1 P11230 3/20 0.39
CHRNA4 P43681 2/20 0.39
CHRNG P07510 1/20 0.39
CHRND Q07001 1/20 0.39
CHRNA2 Q15822 1/20 0.39
CHRNB3 Q05901 2/20 0.37
HDAC4 P56524 1/20 0.36
CYP11B1 P15538 1/20 0.35
CYP11B2 P19099 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7101650 0.82 JAK2 (0.45) CHRNB4CHRNA3CHRNB2CHRNA1CHRNB1
SCHEMBL27592628 0.82 CHRNB4 (0.58) CHRNB4CHRNA3CHRNB2CHRNA1CHRNB1
SCHEMBL7098412 0.78 RIPK1 (0.43) CHRNB4CHRNA3CHRNB2CHRNA1CHRNB1
SCHEMBL7097552 0.77 RIPK1 (0.42) CHRNB4CHRNA3CHRNB2CHRNA1CHRNB1
SCHEMBL7097541 0.77 CHRNB2 (0.43) CHRNB4CHRNA3CHRNB2CHRNA1CHRNB1
SCHEMBL7101836 0.76 CHRNA3 (0.51) CHRNB4CHRNA3CHRNB2CHRNA1CHRNB1
SCHEMBL7099210 0.76 CHRNA3 (0.69) CHRNB4CHRNA3CHRNB2CHRNA1CHRNB1
SCHEMBL6577487 0.74 CHRNB4 (0.40) CHRNB4CHRNA3CHRNB2CHRNA1CHRNB1
SCHEMBL7101239 0.73
SCHEMBL7103958 0.73 PROKR1 (0.36) CHRNB4CHRNA3CHRNB2CHRNB1CHRNB3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2003500402-A 2003-01-07 JP claimed
EP-1178982-A1 HETEROCYCLIC SUBSTITUTED AMINOAZACYCLES USEFUL AS CENTRAL NERVOUS SYSTEM AGENTS ABBOTT LABORATORIES (US) 2002-02-13 EP claimed
WO-2000071534-A1 HETEROCYCLIC SUBSTITUTED AMINOAZACYCLES USEFUL AS CENTRAL NERVOUS SYSTEM AGENTS ABBOTT LABORATORIES (US) 2000-11-30 WO claimed
EP-1178982-A1 HETEROCYCLIC SUBSTITUTED AMINOAZACYCLES USEFUL AS CENTRAL NERVOUS SYSTEM AGENTS ABBOTT LABORATORIES (US) 2002-02-13 EP disclosed
WO-2000071534-A1 HETEROCYCLIC SUBSTITUTED AMINOAZACYCLES USEFUL AS CENTRAL NERVOUS SYSTEM AGENTS ABBOTT LABORATORIES (US) 2000-11-30 WO disclosed