Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.66 |
| ▸ | MAPT | P10636 | 5/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.66 |
| ▸ | MEN1 | O00255 | 2/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.66 |
| ▸ | AHR | P35869 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 4/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.61 |
| ▸ | RAB9A | P51151 | 3/20 | 0.61 |
| ▸ | NPC1 | O15118 | 2/20 | 0.61 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | THRB | P10828 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | DHODH | Q02127 | 3/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | ACHE | P22303 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | ACACA | Q13085 | 2/20 | 0.55 |
| ▸ | BACE1 | P56817 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL951744 | 0.96 | MAPT (0.65) | ALDH1A1MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL17600557 | 0.94 | ALDH1A1 (0.63) | ALDH1A1MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL30388558 | 0.94 | ALDH1A1 (0.63) | ALDH1A1MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL30946935 | 0.94 | ALDH1A1 (0.63) | ALDH1A1MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL6859623 | 0.94 | ALDH1A1 (0.63) | ALDH1A1MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL27986152 | 0.94 | ALDH1A1 (0.63) | ALDH1A1MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL26456461 | 0.91 | ALDH1A1 (0.64) | ALDH1A1MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL670646 | 0.89 | CYP1A2 (0.62) | ALDH1A1MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL10944758 | 0.88 | ALDH1A1 (0.61) | ALDH1A1MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL30028973 | 0.88 | ALDH1A1 (0.61) | ALDH1A1MAPTSMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8124625-B2 | enhancing the expression of apoAI; prevention or therapy of dislipidemia | SHIONOGI & CO., LTD. (JP) | 2012-02-28 | — | — | US | disclosed |
| US-8053445-B2 | Utilities of olefin derivatives | SHIONOGI & CO., LTD. (JP) | 2011-11-08 | — | — | US | disclosed |
| EP-2168576-A2 | New utilities of tricyclic compounds | Shionogi & Co., Ltd. (JP) | 2010-03-31 | — | — | EP | disclosed |
| US-20090036457-A1 | Utilities of olefin derivatives | YAMAMORI TERUO | 2009-02-05 | — | — | US | disclosed |
| US-20080318958-A1 | New utilities of tricyclic compounds | ISHIZUKA NATSUKI | 2008-12-25 | — | — | US | disclosed |
| US-20080318958-A1 | New utilities of tricyclic compounds | ISHIZUKA NATSUKI | 2008-12-25 | — | — | US | disclosed |
| US-20040242615-A1 | Utilities of olefin derivatives | SHIONOGI & CO., LTD. (JP) | 2004-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040242615-A1 | Utilities of olefin derivatives | APOL1, NR1H2, APOB | ALDH1A1 1967/4885MAPT 3896/4885SMN1; SMN2 1814/4885 |
| US-20080318958-A1 | New utilities of tricyclic compounds | APOB, PON1, APOL1 | ALDH1A1 934/4885MAPT 4593/4885SMN1; SMN2 2752/4885 |
| US-20090036457-A1 | Utilities of olefin derivatives | APOL1, APOB, NR1H2 | ALDH1A1 1938/4885MAPT 3909/4885SMN1; SMN2 1978/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.