Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 13/20 | 0.48 |
| ▸ | CTSL | P07711 | 6/20 | 0.46 |
| ▸ | CTSS | P25774 | 4/20 | 0.46 |
| ▸ | CTSB | P07858 | 2/20 | 0.46 |
| ▸ | ITGB1 | P05556 | 5/20 | 0.45 |
| ▸ | ITGA4 | P13612 | 5/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5683187 | 0.89 | ITGB1 (0.54) | ITGB1ITGA4 | |
| SCHEMBL11176046 | 0.87 | STAT3 (0.49) | CTSKCTSLCTSS | |
| SCHEMBL11333776 | 0.87 | STAT3 (0.49) | CTSKCTSLCTSS | |
| SCHEMBL11172309 | 0.87 | STAT3 (0.49) | CTSKCTSLCTSS | |
| SCHEMBL11328272 | 0.86 | MEN1 (0.51) | CTSKCTSLCTSS | |
| SCHEMBL11178329 | 0.85 | CTSK (0.48) | CTSKCTSLCTSSCTSB | |
| SCHEMBL10903528 | 0.82 | CTRB1 (0.42) | CTSKCTSLCTSSCTSB | |
| SCHEMBL10903526 | 0.82 | CTRB1 (0.42) | CTSKCTSLCTSSCTSB | |
| SCHEMBL5683115 | 0.82 | YAP1 (0.47) | ITGB1ITGA4 | |
| SCHEMBL7106067 | 0.81 | ITGB1 (0.40) | CTSKITGB1ITGA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1019434-B1 | INHIBITORS OF METALLOPROTEINASES, THEIR THERAPEUTIC USE, AND PROCESS FOR THE PRODUCTION OF THE STARTING COMPOUND IN THEIR SYNTHESIS | POLIFARMA SPA (IT) | 2003-10-01 | — | — | EP | disclosed |
| US-6339160-B1 | FOR THERAPY OF TUMORAL GROWTH AND METASTATIZATION, ATEROSCLEROSIS, MULTIPLE SCLEROSIS, ALZHEIMER'S DISEASE, OSTEOPOROSIS, HYPERTENSION, RHEUMATOID ARTHRITIS AND OTHER INFLAMMATORY DISEASES | POLIFARMA S.P.A. (IT) | 2002-01-15 | — | — | US | disclosed |
| EP-1019434-A2 | INHIBITORS OF METALLOPROTEINASES, THEIR THERAPEUTIC USE, AND PROCESS FOR THE PRODUCTION OF THE STARTING COMPOUND IN THEIR SYNTHESIS | POLIFARMA S.p.A. (IT) | 2000-07-19 | — | — | EP | disclosed |
| WO-1999003878-A2 | INHIBITORS OF METALLOPROTEINASES, THEIR THERAPEUTIC USE, AND PROCESS FOR THE PRODUCTION OF THE STARTING COMPOUND IN THEIR SYNTHESIS | POLIFARMA S.P.A. (IT) | 1999-01-28 | — | — | WO | disclosed |