Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.31 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.30 |
| ▸ | CES2 | O00748 | 1/20 | 0.30 |
| ▸ | CES1 | P23141 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1040893 | 0.97 | TP53 (0.41) | TP53ALDH1A1PSIP1SMN1; SMN2L3MBTL1 | |
| SCHEMBL21810707 | 0.94 | TP53 (0.39) | TP53ALDH1A1PSIP1SMN1; SMN2L3MBTL1 | |
| Tetramethylammonium Ion SCHEMBL7094906 | 0.90 | TP53 (0.36) | TP53ALDH1A1PSIP1SMN1; SMN2L3MBTL1 | |
| SCHEMBL4385849 | 0.85 | LMNA (0.37) | TP53LMNATSHRMEN1KMT2A | |
| Tetraphenylphosphonium SCHEMBL1209546 | 0.84 | HIF1A (0.36) | TP53LMNA | |
| Lithium Ion SCHEMBL4652452 | 0.78 | TP53 (0.39) | TP53ALDH1A1PSIP1SMN1; SMN2L3MBTL1 | |
| Lithium Ion SCHEMBL20543346 | 0.76 | TP53 (0.38) | TP53ALDH1A1PSIP1SMN1; SMN2L3MBTL1 | |
| SCHEMBL1042058 | 0.76 | TP53 (0.38) | TP53ALDH1A1PSIP1SMN1; SMN2L3MBTL1 | |
| Lithium Ion SCHEMBL503758 | 0.75 | TSHR (0.37) | TP53SMN1; SMN2TSHRCES2CES1 | |
| SCHEMBL15065197 | 0.74 | TP53 (0.41) | TP53ALDH1A1PSIP1SMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0922708-B1 | Production method of borate compounds | SHOWA DENKO KK (JP) | 2003-05-14 | — | — | EP | disclosed |
| US-6002044-A | REACTING A LITHIUM OR MAGNEISIUM, A HALIDE AND A BORONATE PRECURSOR OBTAINED IN A FIRSST SIMILAR STEP USING A BORIDE; ADDING AN ONIIUM HALIDE TO THE METAL BORATE; PURITY | SHOWA DENKO K.K. (JP) | 1999-12-14 | — | — | US | disclosed |
| EP-0922708-A2 | Production method of borate compounds | SHOWA DENKO KABUSHIKI KAISHA (JP) | 1999-06-16 | — | — | EP | disclosed |