Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNP | P00491 | 2/20 | 0.38 |
| ▸ | TRPV3 | Q8NET8 | 7/20 | 0.35 |
| ▸ | TYMP | P19971 | 3/20 | 0.33 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MTAP | Q13126 | 3/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7663658 | 0.81 | CXCR4 (0.35) | PNPTRPV3PDCD1CD274ALDH1A1 | |
| SCHEMBL7110102 | 0.78 | TRPV3 (0.34) | PNPTRPV3TYMPALDH1A1CA2 | |
| SCHEMBL7103658 | 0.75 | PNP (0.43) | PNPTRPV3MTAP | |
| SCHEMBL7662208 | 0.74 | TRPV3 (0.46) | TRPV3 | |
| SCHEMBL7106706 | 0.73 | PNP (0.31) | PNPTRPV3 | |
| SCHEMBL7663759 | 0.70 | TYMP (0.35) | PNPTYMPPDCD1CD274ALDH1A1 | |
| SCHEMBL7104789 | 0.70 | PNP (0.41) | PNPMEN1KMT2AMTAP | |
| SCHEMBL7071084 | 0.69 | PNP (0.39) | PNPTRPV3MTAP | |
| SCHEMBL7075461 | 0.69 | PNP (0.39) | PNPTRPV3MTAP | |
| SCHEMBL7072329 | 0.69 | PNP (0.39) | PNPTRPV3MTAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001944-B1 | PYRAZINE DERIVATIVES, PREPARATION AND MEDICINES CONTAINING THEM | AVENTIS PHARMA SA (FR) | 2003-10-01 | — | — | EP | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | claimed |
| EP-1001944-B1 | PYRAZINE DERIVATIVES, PREPARATION AND MEDICINES CONTAINING THEM | AVENTIS PHARMA SA (FR) | 2003-10-01 | — | — | EP | disclosed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | disclosed |