Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNP | P00491 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MTAP | Q13126 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7662068 | 0.82 | CXCR4 (0.43) | PNPKDM4EMEN1KMT2A | |
| SCHEMBL7103571 | 0.82 | PNP (0.42) | PNPKDM4E | |
| SCHEMBL7106463 | 0.80 | PNP (0.36) | PNP | |
| SCHEMBL7105047 | 0.80 | PNP (0.43) | PNPKDM4E | |
| SCHEMBL7663595 | 0.76 | TRPV3 (0.44) | PNPKDM4E | |
| SCHEMBL7663573 | 0.72 | PNP (0.36) | PNP | |
| SCHEMBL7107801 | 0.70 | PNP (0.38) | PNPMTAPMEN1KMT2A | |
| SCHEMBL6468950 | 0.67 | MEN1 (0.44) | MEN1KMT2A | |
| SCHEMBL14279028 | 0.67 | OPRM1 (0.39) | KDM4EMEN1KMT2A | |
| SCHEMBL7657692 | 0.66 | CD274 (0.46) | PNPKDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001944-B1 | PYRAZINE DERIVATIVES, PREPARATION AND MEDICINES CONTAINING THEM | AVENTIS PHARMA SA (FR) | 2003-10-01 | — | — | EP | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | disclosed |