Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV3 | Q8NET8 | 6/20 | 0.34 |
| ▸ | PNP | P00491 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | TYMP | P19971 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | UPP1 | Q16831 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7106706 | 0.80 | PNP (0.31) | TRPV3PNP | |
| SCHEMBL7662208 | 0.79 | TRPV3 (0.46) | TRPV3 | |
| SCHEMBL7107801 | 0.78 | PNP (0.38) | TRPV3PNPCA2TYMPALDH1A1 | |
| SCHEMBL7108751 | 0.77 | PNP (0.39) | TRPV3PNP | |
| SCHEMBL7663759 | 0.75 | TYMP (0.35) | PNPCA2TYMPALDH1A1 | |
| SCHEMBL7106463 | 0.72 | PNP (0.36) | TRPV3PNP | |
| SCHEMBL7108772 | 0.71 | PNP (0.38) | PNPTYMPUPP1 | |
| SCHEMBL7108663 | 0.69 | PNP (0.39) | PNP | |
| SCHEMBL7663658 | 0.69 | CXCR4 (0.35) | TRPV3PNPALDH1A1 | |
| SCHEMBL7109310 | 0.68 | VSIR (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001944-B1 | PYRAZINE DERIVATIVES, PREPARATION AND MEDICINES CONTAINING THEM | AVENTIS PHARMA SA (FR) | 2003-10-01 | — | — | EP | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | disclosed |