SCHEMBL7107983

SCHEMBL7107983

CC(C)(C)OC(=O)CC(=O)CBr

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FAAH O00519 5/20 0.44
CNR1 P21554 1/20 0.40
CNR2 P34972 1/20 0.40
DGAT1 O75907 1/20 0.37
CYP2D6 P10635 1/20 0.36
AKT1 P31749 1/20 0.35
TRPA1 O75762 2/20 0.34
ALDH1A1 P00352 1/20 0.34
CA2 P00918 2/20 0.34
CA12 O43570 1/20 0.34
CA14 Q9ULX7 1/20 0.34
TDP1 Q9NUW8 1/20 0.33
EPHX2 P34913 1/20 0.33
CA1 P00915 1/20 0.32
CA7 P43166 1/20 0.32
MTNR1A P48039 1/20 0.32
MTNR1B P49286 1/20 0.32
CYP1A2 P05177 1/20 0.32
CYP2C9 P11712 1/20 0.32
CYP2C19 P33261 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2648388 0.85 DGAT1 (0.42) DGAT1CYP2D6CA2CA12CA14
SCHEMBL12305755 0.80
SCHEMBL29015869 0.80 TRPA1 (0.46) DGAT1CYP2D6AKT1TRPA1ALDH1A1
SCHEMBL38493 0.80
SCHEMBL28247512 0.80 STING1 (0.36) FAAHDGAT1CYP2D6AKT1TRPA1
SCHEMBL241533 0.80 DGAT1 (0.46) DGAT1CYP2D6ALDH1A1CA2CA12
SCHEMBL10833684 0.79 TDP1 (0.38) DGAT1CYP2D6CA2CA12CA14
SCHEMBL182237 0.79 TDP1 (0.41) DGAT1CYP2D6ALDH1A1CA2CA12
Ammonia Solution, Strong SCHEMBL22577671 0.78 TRPA1 (0.44) DGAT1CYP2D6AKT1TRPA1ALDH1A1
SCHEMBL15456193 0.78 TRPA1 (0.44) DGAT1CYP2D6AKT1TRPA1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-61000063-A None JP disclosed
CN-109574830-B Rosuvastatin calcium intermediate, and preparation method and application thereof 浙江宏元药业股份有限公司 2021-04-13 CN disclosed
CN-109503542-B Atorvastatin calcium intermediate and preparation method and application thereof 浙江宏元药业股份有限公司 2020-08-18 CN disclosed
CN-110172051-A IRE-1 alpha inhibitor 复星弘创(苏州)医药科技有限公司 2019-08-27 CN disclosed
CN-107082770-B IRE-1 alpha inhibitor 复星弘创(苏州)医药科技有限公司 2019-04-23 CN disclosed
CN-109574830-A A kind of rosuvastain calcium intermediate and its preparation method and application 浙江宏元药业股份有限公司 2019-04-05 CN disclosed
CN-109503542-A A kind of Atorvastatin calcium intermediate and its preparation method and application 浙江宏元药业股份有限公司 2019-03-22 CN disclosed
CN-1158241-C Processfor prepn. of 2-nialkyl 4-bromo-acetoacetic ester ס�ѻ�ѧ��ҵ��ʽ���� 2004-07-21 CN disclosed
EP-0999202-B1 Process for producing 2-alkylidene-4-bromoacetoacetic acid ester SUMITOMO CHEMICAL CO (JP) 2003-03-19 EP disclosed
US-6469200-B1 A PROCESS WHICH CAN PROVIDE THE DESIRED 2-ALKYLIDENE-4-BROMOACETOACETIC ACID ESTER BY USING, AS A STARTING MATERIAL, A 4-BROMOACETOACETIC ACID ESTER WHICH CAN BE READILY DERIVED FROM AN ACETOACETIC ACID ESTER SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2002-10-22 US disclosed
CN-1255488-A Processfor prepn. of 2-nialkyl 4-bromo-acetoacetic ester SUMITOMO CHEM ENG (JP) 2000-06-07 CN disclosed
EP-0999202-A1 Process for producing 2-alkylidene-4-bromoacetoacetic acid ester SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2000-05-10 EP disclosed
EP-0339764-B1 PROCESS FOR PREPARING CARNITINE Takasago International Corporation (JP) 1992-06-24 EP disclosed
US-4895979-A HYDROGENATION OF GAMMA-HALO-BETA-KETO ESTER, RUTHENIUM-OPTICALLY ACTIVE PHOSPHINE CATALYST, QUATERNIZATION TAKASAGO INTERNATIONAL CORPORATION (JP) 1990-01-23 US disclosed
EP-0339764-A1 Process for preparing carnitine Takasago International Corporation (JP) 1989-11-02 EP disclosed
US-4716158-A CEPHALOSPORINS SUITABLE FOR ORAL ADMINISTRATION SANKYO COMPANY LIMITED (JP) 1987-12-29 US disclosed
EP-0049118-B1 CEPHALOSPORIN DERIVATIVES, THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM SANKYO COMPANY LIMITED (JP) 1986-04-23 EP disclosed
JP-S6163-A 2-ALKOXYIMINOBUTYRIC ACID DERIVATIVE SANKYO CO LTD 1986-01-06 JP disclosed
US-4486425-A ANTIBIOTICS SANKYO COMPANY LIMITED (JP) 1984-12-04 US disclosed
EP-0049118-A2 Cephalosporin derivatives, their preparation and compositions containing them SANKYO COMPANY LIMITED (JP) 1982-04-07 EP disclosed