Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.64 |
| ▸ | HPGD | P15428 | 2/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.64 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | SORT1 | Q99523 | 13/20 | 0.50 |
| ▸ | CES2 | O00748 | 2/20 | 0.49 |
| ▸ | LIPC | P11150 | 1/20 | 0.46 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.46 |
| ▸ | CFTR | P13569 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 1/20 | 0.45 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30184263 | 0.98 | KDM4E (0.66) | KDM4EALDH1A1HPGDHSD17B10USP2 | |
| SCHEMBL460066 | 0.87 | KDM4E (0.69) | KDM4EALDH1A1HPGDHSD17B10USP2 | |
| SCHEMBL7457551 | 0.81 | CFTR (0.49) | KDM4EALDH1A1HPGDHSD17B10USP2 | |
| SCHEMBL168327 | 0.80 | KDM4E (0.61) | KDM4EALDH1A1HPGDHSD17B10USP2 | |
| SCHEMBL15141378 | 0.79 | KDM4E (0.47) | KDM4EALDH1A1HPGDHSD17B10SORT1 | |
| SCHEMBL9541475 | 0.79 | ALDH1A1 (0.59) | KDM4EALDH1A1HPGDHSD17B10USP2 | |
| SCHEMBL2920377 | 0.78 | DGAT1 (0.56) | KDM4EALDH1A1HPGDHSD17B10USP2 | |
| SCHEMBL1002163 | 0.78 | CES2 (0.72) | KDM4EALDH1A1HPGDHSD17B10USP2 | |
| SCHEMBL2313990 | 0.78 | ALDH1A1 (0.58) | KDM4EALDH1A1HPGDHSD17B10CES2 | |
| SCHEMBL955863 | 0.78 | ALDH1A1 (1.00) | KDM4EALDH1A1HPGDHSD17B10USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1343751-A2 | CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-09-17 | — | — | EP | disclosed |
| WO-2002060859-A2 | CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-08-08 | — | — | WO | disclosed |