Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.40 |
| ▸ | SELE | P16581 | 1/20 | 0.40 |
| ▸ | MAP2K1 | Q02750 | 5/20 | 0.40 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.40 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.40 |
| ▸ | IARS2 | Q9NSE4 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7109193 | 0.94 | ICAM1 (0.40) | CNR2ICAM1SELEMAP2K1MAP2K2 | |
| SCHEMBL7103645 | 0.85 | SCN10A (0.35) | KDM4EALDH1A1HPGDPRMT5WDR77 | |
| SCHEMBL7108548 | 0.84 | SCN10A (0.37) | KDM4EALDH1A1HPGDLMNA | |
| SCHEMBL7655302 | 0.83 | CNR2 (0.50) | CNR2CA2KDM4EALDH1A1HPGD | |
| SCHEMBL7105165 | 0.82 | MAP2K1 (0.41) | CNR2ICAM1SELEMAP2K1MAP2K2 | |
| SCHEMBL28237026 | 0.82 | SMN1; SMN2 (0.54) | KDM4EALDH1A1HPGDLMNACYP2C19 | |
| SCHEMBL7104658 | 0.80 | SMN1; SMN2 (0.35) | KDM4EALDH1A1HPGDLMNACYP2C19 | |
| SCHEMBL7652930 | 0.79 | KDM4E (0.49) | ICAM1SELEMAP2K1MAP2K2PRKCZ | |
| SCHEMBL7652131 | 0.77 | CNR1 (0.34) | — | |
| SCHEMBL7108875 | 0.76 | CYP2C19 (0.31) | CNR2ICAM1SELEMAP2K1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001944-B1 | PYRAZINE DERIVATIVES, PREPARATION AND MEDICINES CONTAINING THEM | AVENTIS PHARMA SA (FR) | 2003-10-01 | — | — | EP | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | disclosed |