Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | CNR1 | P21554 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.33 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.33 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.33 |
| ▸ | PSMA1 | P25786 | 1/20 | 0.33 |
| ▸ | PSMA2 | P25787 | 1/20 | 0.33 |
| ▸ | PSMA3 | P25788 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7103645 | 0.94 | SCN10A (0.35) | SMN1; SMN2HPGDCNR1LMNAKDM4E | |
| SCHEMBL7110167 | 0.91 | ALDH1A1 (0.38) | SMN1; SMN2HPGDCYP1A2POLBCYP2C9 | |
| SCHEMBL7109193 | 0.87 | ICAM1 (0.40) | SMN1; SMN2HPGDKDM4EALDH1A1 | |
| SCHEMBL7108469 | 0.80 | CNR2 (0.41) | HPGDLMNACYP2C19KDM4EALDH1A1 | |
| SCHEMBL7109870 | 0.79 | CNR1 (0.44) | CNR1KDM4ERAB9APSMB11PSMA7 | |
| SCHEMBL7654531 | 0.78 | LMNA (0.47) | HPGDLMNAPOLBKDM4EALDH1A1 | |
| SCHEMBL7108548 | 0.78 | SCN10A (0.37) | SMN1; SMN2HPGDCNR1LMNAKDM4E | |
| SCHEMBL7103718 | 0.78 | CNR1 (0.52) | SMN1; SMN2HPGDCNR1LMNAKDM4E | |
| SCHEMBL7663932 | 0.77 | ALDH1A1 (0.44) | SMN1; SMN2LMNAPOLBKDM4ERAB9A | |
| SCHEMBL8061648 | 0.76 | ALDH1A1 (0.42) | SMN1; SMN2LMNAPOLBKDM4ERAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001944-B1 | PYRAZINE DERIVATIVES, PREPARATION AND MEDICINES CONTAINING THEM | AVENTIS PHARMA SA (FR) | 2003-10-01 | — | — | EP | claimed |
| EP-1001944-B1 | PYRAZINE DERIVATIVES, PREPARATION AND MEDICINES CONTAINING THEM | AVENTIS PHARMA SA (FR) | 2003-10-01 | — | — | EP | disclosed |