Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.37 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7108469 | 0.84 | CNR2 (0.41) | KDM4EALDH1A1LMNAHPGD | |
| SCHEMBL7103645 | 0.83 | SCN10A (0.35) | SCN10ASCN2ASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL7658648 | 0.82 | LMNA (0.50) | KDM4EALDH1A1LMNAHPGD | |
| SCHEMBL7104694 | 0.81 | HPGD (0.37) | SMN1; SMN2ALDH1A1LMNAHPGDCNR1 | |
| SCHEMBL7109193 | 0.79 | ICAM1 (0.40) | SMN1; SMN2KDM4EALDH1A1HPGD | |
| SCHEMBL7661579 | 0.79 | KDM4E (0.50) | SCN10ASCN2ASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL7104658 | 0.78 | SMN1; SMN2 (0.35) | SCN10ASCN2ASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL7109274 | 0.77 | CNR1 (0.50) | SCN10ASCN2AKDM4EALDH1A1HSD17B10 | |
| SCHEMBL7108034 | 0.74 | CNR1 (0.44) | CNR1 | |
| SCHEMBL7661497 | 0.73 | ALDH1A1 (0.46) | SMN1; SMN2KDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001944-B1 | PYRAZINE DERIVATIVES, PREPARATION AND MEDICINES CONTAINING THEM | AVENTIS PHARMA SA (FR) | 2003-10-01 | — | — | EP | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | disclosed |