Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNP | P00491 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7108772 | 0.84 | PNP (0.38) | PNPKDM4E | |
| SCHEMBL7650049 | 0.82 | TRPV3 (0.43) | PNPKDM4E | |
| SCHEMBL7106463 | 0.81 | PNP (0.36) | PNP | |
| SCHEMBL7105047 | 0.81 | PNP (0.43) | PNPKDM4E | |
| SCHEMBL7655578 | 0.79 | PNP (0.39) | PNP | |
| SCHEMBL7108751 | 0.75 | PNP (0.39) | PNP | |
| SCHEMBL7107159 | 0.75 | LMNA (0.31) | — | |
| SCHEMBL7109077 | 0.75 | LMNA (0.31) | — | |
| SCHEMBL7109071 | 0.75 | LMNA (0.31) | — | |
| SCHEMBL7654878 | 0.73 | CXCR4 (0.41) | PNPKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001944-B1 | PYRAZINE DERIVATIVES, PREPARATION AND MEDICINES CONTAINING THEM | AVENTIS PHARMA SA (FR) | 2003-10-01 | — | — | EP | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | disclosed |