Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV3 | Q8NET8 | 6/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PNP | P00491 | 2/20 | 0.39 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.38 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PGK1 | P00558 | 1/20 | 0.32 |
| ▸ | PGK2 | P07205 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7656011 | 0.84 | TRPV3 (0.43) | TRPV3NPSR1KDM4EPNPCXCR4 | |
| SCHEMBL7108663 | 0.82 | PNP (0.39) | KDM4EPNP | |
| SCHEMBL7663595 | 0.81 | TRPV3 (0.44) | TRPV3NPSR1KDM4EPNPCXCR4 | |
| SCHEMBL7105047 | 0.78 | PNP (0.43) | KDM4EPNPDNM1 | |
| SCHEMBL7659507 | 0.75 | TRPV3 (0.52) | TRPV3NPSR1PNP | |
| SCHEMBL11670929 | 0.73 | KDM4E (0.61) | KDM4EPNPDNM1SMN1; SMN2 | |
| SCHEMBL7654878 | 0.73 | CXCR4 (0.41) | KDM4EPNPCXCR4DNM1SMN1; SMN2 | |
| SCHEMBL7653614 | 0.71 | CXCR4 (0.47) | NPSR1CXCR4SMN1; SMN2 | |
| SCHEMBL7662208 | 0.69 | TRPV3 (0.46) | TRPV3NPSR1CXCR4 | |
| SCHEMBL8529667 | 0.68 | LMNA (0.44) | KDM4EPNP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | disclosed |