Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNP | P00491 | 2/20 | 0.38 |
| ▸ | TYMP | P19971 | 1/20 | 0.36 |
| ▸ | UPP1 | Q16831 | 1/20 | 0.35 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.31 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.30 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7108663 | 0.84 | PNP (0.39) | PNPKDM4E | |
| SCHEMBL7106463 | 0.83 | PNP (0.36) | PNP | |
| SCHEMBL7656011 | 0.81 | TRPV3 (0.43) | PNPTYMPDNM1KDM4EPDCD1 | |
| SCHEMBL7103571 | 0.81 | PNP (0.42) | PNPTYMPUPP1DNM1KDM4E | |
| SCHEMBL7659608 | 0.78 | PNP (0.38) | PNPTYMPUPP1DNM1PDCD1 | |
| SCHEMBL7657692 | 0.73 | CD274 (0.46) | PNPDNM1KDM4EPDCD1CD274 | |
| SCHEMBL7109310 | 0.72 | VSIR (0.38) | PDCD1CD274 | |
| SCHEMBL7110102 | 0.71 | TRPV3 (0.34) | PNPTYMPUPP1 | |
| SCHEMBL27756230 | 0.70 | TYMP (0.40) | PNPTYMPUPP1DNM1KDM4E | |
| SCHEMBL27777044 | 0.70 | TYMP (0.40) | PNPTYMPUPP1DNM1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001944-B1 | PYRAZINE DERIVATIVES, PREPARATION AND MEDICINES CONTAINING THEM | AVENTIS PHARMA SA (FR) | 2003-10-01 | — | — | EP | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | disclosed |