Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.49 |
| ▸ | BCHE | P06276 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL709144 | 0.97 | BCHE (0.65) | BCHEGAADDAH1POLBNPC1 | |
| SCHEMBL5137719 | 0.95 | BCHE (0.63) | BCHEGAADDAH1POLBNPC1 | |
| Hydrochloric Acid SCHEMBL710872 | 0.94 | BCHE (0.61) | BCHEGAADDAH1POLBNPC1 | |
| SCHEMBL7337463 | 0.91 | GAA (0.59) | BCHEGAADDAH1POLBNPC1 | |
| Hydrochloric Acid SCHEMBL709918 | 0.80 | TDP1 (0.67) | BCHEGAADDAH1POLBNPC1 | |
| Hydrochloric Acid SCHEMBL710646 | 0.79 | BCHE (0.69) | BCHEGAADDAH1POLBNPC1 | |
| SCHEMBL29550341 | 0.79 | BCHE (0.86) | BCHEGAADDAH1POLBNPC1 | |
| SCHEMBL370724 | 0.79 | BCHE (0.86) | BCHEGAADDAH1POLBNPC1 | |
| Magnesium SCHEMBL30119882 | 0.78 | BCHE (0.83) | BCHEGAADDAH1POLBNPC1 | |
| Hydrochloric Acid SCHEMBL710081 | 0.77 | BCHE (0.68) | BCHEGAAPOLBNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910426-B1 | DIENE POLYMERISATION | INEOS SALES (UK) LTD (GB) | 2018-01-03 | — | — | EP | disclosed |
| US-8124698-B2 | Diene polymerisation | INEOS EUROPE LIMITED (GB) | 2012-02-28 | — | — | US | disclosed |
| US-20100022724-A1 | Diene Polymerisation | INEOS SALES (UK) LIMITED (GB) | 2010-01-28 | — | — | US | disclosed |