Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 8/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | PDE5A | O76074 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 2/20 | 0.33 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.33 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7105213 | 0.93 | CNR2 (0.39) | CNR2KDM4EGLAL3MBTL1PDE5A | |
| SCHEMBL7658923 | 0.81 | CNR2 (0.53) | CNR2KDM4EL3MBTL1PDE5AKMT2A | |
| SCHEMBL7107999 | 0.80 | CNR2 (0.44) | CNR2KDM4EGLAL3MBTL1PDE5A | |
| SCHEMBL7660743 | 0.77 | KDM4E (0.47) | KDM4EGLAL3MBTL1KMT2A | |
| SCHEMBL7656358 | 0.72 | ALDH1A1 (0.49) | CNR2KDM4EGLAL3MBTL1KMT2A | |
| SCHEMBL7108034 | 0.69 | CNR1 (0.44) | CNR2CNR1 | |
| SCHEMBL19283447 | 0.69 | KDM4E (0.54) | CNR2KDM4EGLAL3MBTL1 | |
| SCHEMBL11253022 | 0.69 | KDM4E (0.50) | KDM4EGLAL3MBTL1 | |
| SCHEMBL24609419 | 0.67 | CNR2 (0.38) | CNR2L3MBTL1PDE5ACNR1 | |
| SCHEMBL158634 | 0.67 | ALDH1A1 (0.36) | CNR2KDM4EGLAL3MBTL1GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001944-B1 | PYRAZINE DERIVATIVES, PREPARATION AND MEDICINES CONTAINING THEM | AVENTIS PHARMA SA (FR) | 2003-10-01 | — | — | EP | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | disclosed |