Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.53 |
| ▸ | PDE5A | O76074 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7656385 | 0.81 | KMT2A (0.56) | CNR2POLBLMNAP2RX7KDM4E | |
| SCHEMBL7108736 | 0.81 | CNR2 (0.38) | CNR2PDE5AKDM4EL3MBTL1KMT2A | |
| SCHEMBL18157899 | 0.76 | POLB (0.50) | CNR2POLBLMNAP2RX7KDM4E | |
| SCHEMBL20283772 | 0.76 | P2RX7 (0.51) | POLBLMNAP2RX7KDM4ETDP1 | |
| SCHEMBL7107999 | 0.76 | CNR2 (0.44) | CNR2PDE5AKDM4EL3MBTL1KMT2A | |
| SCHEMBL7105213 | 0.75 | CNR2 (0.39) | CNR2PDE5APOLBKDM4ESMN1; SMN2 | |
| SCHEMBL1142172 | 0.73 | P2RX7 (0.74) | POLBLMNAP2RX7KDM4ETDP1 | |
| SCHEMBL11253022 | 0.73 | KDM4E (0.50) | POLBLMNAKDM4EGAANPC1 | |
| SCHEMBL7654754 | 0.72 | LMNA (0.66) | POLBLMNAP2RX7KDM4ETDP1 | |
| SCHEMBL16475559 | 0.72 | POLB (0.55) | POLBLMNAKDM4ETDP1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | disclosed |