Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5220657 | 0.98 | IDO1 (0.57) | IDO1RAB9AAKR1C3MAPTLOXL2 | |
| SCHEMBL6046636 | 0.83 | RAB9A (0.59) | IDO1RAB9AAKR1C3MAPTLOXL2 | |
| SCHEMBL6562098 | 0.82 | IDO1 (0.61) | IDO1RAB9AAKR1C3LOXL2NPC1 | |
| Hydrochloric Acid SCHEMBL11574226 | 0.81 | IDO1 (0.58) | IDO1RAB9AAKR1C3MAPTLOXL2 | |
| SCHEMBL28502948 | 0.80 | IDO1 (0.58) | IDO1RAB9AAKR1C3LOXL2ALDH1A1 | |
| SCHEMBL8601259 | 0.79 | IDO1 (0.56) | IDO1RAB9AAKR1C3MAPTALDH1A1 | |
| SCHEMBL1555636 | 0.77 | ALDH1A1 (0.59) | IDO1RAB9AAKR1C3MAPTALDH1A1 | |
| SCHEMBL1013 | 0.77 | IDO1 (0.62) | IDO1RAB9AAKR1C3LOXL2ALDH1A1 | |
| SCHEMBL2299040 | 0.77 | IDO1 (0.58) | IDO1RAB9AAKR1C3MAPTNPC1 | |
| SCHEMBL10509450 | 0.77 | HTT (0.50) | IDO1RAB9AAKR1C3MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1351934-A1 | NAPHTHALENE DERIVATIVES WHICH BIND TO THE EP4 RECEPTOR | GLAXO GROUP LIMITED (GB) | 2003-10-15 | — | — | EP | disclosed |
| WO-2002050032-A1 | NAPHTHALENE DERIVATIVES WHICH BIND TO THE EP4 RECEPTOR | GLAXO GROUP LIMITED (GB) | 2002-06-27 | — | — | WO | disclosed |