SCHEMBL7108792

SCHEMBL7108792

CCCC1=Cc2c(-c3ccc(CC)cc3)cccc2C1C[SiH2]CC1C(CCC)=Cc2c(-c3ccc(CC)cc3)cccc21

nearest known ligand 0.33

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
EDNRB P24530 1/20 0.33
EDNRA P25101 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7105397 0.93 EDNRB (0.32) EDNRBEDNRA
SCHEMBL7111659 0.91 DRD2 (0.34) EDNRBEDNRA
SCHEMBL7103915 0.90 HSD11B1 (0.33)
SCHEMBL7108907 0.89 CRHR1 (0.30)
SCHEMBL7108748 0.88 SLC6A2 (0.37)
SCHEMBL7109568 0.88 TLR8 (0.31)
SCHEMBL7106922 0.86 HSD11B1 (0.34)
SCHEMBL7110770 0.86 HSD11B1 (0.34)
SCHEMBL7112132 0.85 BRD4 (0.32)
SCHEMBL3999811 0.84 BRD4 (0.32)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1053263-B1 CATALYST SYSTEM BASELL POLYOLEFINE GMBH (DE) 2003-10-01 EP claimed