Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 4/20 | 0.38 |
| ▸ | MME | P08473 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 5/20 | 0.37 |
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.37 |
| ▸ | PDE9A | O76083 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.35 |
| ▸ | SELE | P16581 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7105165 | 0.91 | MAP2K1 (0.41) | SMOCNR2MAP2K1PDE9AKDM4E | |
| SCHEMBL7105347 | 0.85 | CNR1 (0.46) | CNR1MMECNR2MAP2K1 | |
| SCHEMBL18230701 | 0.83 | SIRT6 (0.42) | SMOCNR2MAP2K1PDE9AKDM4E | |
| SCHEMBL7109193 | 0.82 | ICAM1 (0.40) | SMOCNR2MAP2K1PDE9AKDM4E | |
| SCHEMBL28237026 | 0.77 | SMN1; SMN2 (0.54) | KDM4EALDH1A1HPGD | |
| SCHEMBL7106764 | 0.76 | CNR1 (0.46) | CNR1MMECNR2MAP2K1 | |
| SCHEMBL7656636 | 0.76 | ALDH1A1 (0.47) | MAP2K1KDM4EALDH1A1HPGD | |
| SCHEMBL7110167 | 0.76 | ALDH1A1 (0.38) | CNR2ALDH1A1HPGD | |
| SCHEMBL7104694 | 0.75 | HPGD (0.37) | CNR1ALDH1A1HPGD | |
| SCHEMBL7658603 | 0.74 | MME (0.39) | CNR1MMECNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001944-B1 | PYRAZINE DERIVATIVES, PREPARATION AND MEDICINES CONTAINING THEM | AVENTIS PHARMA SA (FR) | 2003-10-01 | — | — | EP | claimed |