Methabenzthiazuron

Methabenzthiazuron

SCHEMBL7109380

CNC(=O)N(C)c1nc2ccccc2s1.NO

nearest known ligand 0.66

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 2/20 0.66
TSHR P16473 2/20 0.66
ALDH1A1 P00352 6/20 0.63
NPC1 O15118 4/20 0.63
RAB9A P51151 4/20 0.63
LMNA P02545 2/20 0.62
TP53 P04637 1/20 0.62
CASP3 P42574 1/20 0.62
SMN1; SMN2 Q16637 1/20 0.62
SENP8 Q96LD8 1/20 0.62
SENP7 Q9BQF6 1/20 0.62
SENP6 Q9GZR1 1/20 0.62
ADORA1 P30542 1/20 0.46
DYRK1A Q13627 1/20 0.46
ALOX5 P09917 3/20 0.45
USP30 Q70CQ3 2/20 0.45
GAA P10253 3/20 0.43
CYP1A2 P05177 1/20 0.43
KMT2A Q03164 3/20 0.43
MEN1 O00255 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Methabenzthiazuron SCHEMBL19893745 0.97 ALOX15 (0.66) ALOX15TSHRALDH1A1NPC1RAB9A
Methabenzthiazuron SCHEMBL66434 0.97 ALOX15 (0.69) ALOX15TSHRALDH1A1NPC1RAB9A
Methabenzthiazuron SCHEMBL8537244 0.97 ALOX15 (0.69) ALOX15TSHRALDH1A1NPC1RAB9A
Methabenzthiazuron SCHEMBL29549492 0.97 ALOX15 (0.69) ALOX15TSHRALDH1A1NPC1RAB9A
Methabenzthiazuron SCHEMBL28163689 0.94 ALOX15 (0.66) ALOX15TSHRALDH1A1NPC1RAB9A
Methabenzthiazuron SCHEMBL11351797 0.92 ALOX15 (0.63) ALOX15TSHRALDH1A1NPC1RAB9A
Methabenzthiazuron SCHEMBL9451072 0.89 ALOX15 (0.60) ALOX15TSHRALDH1A1NPC1RAB9A
Methabenzthiazuron SCHEMBL27354229 0.89 ALDH1A1 (0.61) ALOX15TSHRALDH1A1NPC1RAB9A
Methabenzthiazuron SCHEMBL11351792 0.89 ALOX15 (0.60) ALOX15TSHRALDH1A1NPC1RAB9A
Methabenzthiazuron SCHEMBL17260861 0.84 CYP3A4 (0.68) ALOX15TSHRALDH1A1NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20030162979-A1 Substituted sulphonylamino(thio)carbonyl compounds MULLER KLAUS-HELMUT (DE) 2003-08-28 US disclosed
CN-1109676-C Substituted aminophenyluracils as herbicides and insecticides BAYER AG (DE) 2003-05-28 CN disclosed
CN-1094725-C N-aryl-1, 2, 4-triazolin-5-ones BAYER AG (DE) 2002-11-27 CN disclosed
CN-1090623-C 3-aryl-1, 2, 4-triazole derivatives having herbicidal properties BAYER AG (DE) 2002-09-11 CN disclosed
CN-1090183-C Sulfonylaminocarboxy triazolinones with haloalkylthio substituents BAYER AG (DE) 2002-09-04 CN disclosed
US-6441195-B1 2-ALKOXYCARBONYL-3-SULPHONAMIDE, SULPHONYL ISOCYANATE OR SULPHONYL ISOTHIOCYANATE-THIOPHENES; PRE- OR POSTEMERGENCE HERBICIDES; EFFICIENCY BAYER AKTIENGESELLSCHAFT (DE) 2002-08-27 US disclosed
CN-1086696-C Sulphonylamino (thio) carbonyl compounds 拜尔公司 2002-06-26 CN disclosed
CN-1084737-C Substituted sulphonyl amino (thio) carbonyl compounds and their use as herbicides BAYER AG (DE) 2002-05-15 CN disclosed
CN-1079398-C Substituted arylsulfonylamino (thio) carbonyl-triazolin (thi) ones as herbicides BAYER AG (DE) 2002-02-20 CN disclosed
CN-1325848-A Herbicidal 3-aryl-1,2,4-triazole derivative BAYER AG (DE) 2001-12-12 CN disclosed
CN-1070855-C 4-thiocarbamoyl-1-(3-pyrazolyl)-pyrazoles and their use as herbicides BAYER AG (DE) 2001-09-12 CN disclosed
CN-1196725-A Substituted aminouracils BAYER AG (DE) 1998-10-21 CN disclosed
CN-1183094-A Herbicidalor fungicidal sulphonylaminocarbonyltria with hologenated alk(en) oxy substituents BAYER AG (DE) 1998-05-27 CN disclosed
CN-1183095-A Herbicidal or fungicidal sulphonylaminocarbonyltriazolinones with halogenated alk(EN)ylthio substituents BAYER AG (DE) 1998-05-27 CN disclosed
CN-1175249-A 3-aryl-1, 2, 4-triazole derivatives having herbicidal properties BAYER AG (DE) 1998-03-04 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030162979-A1 Substituted sulphonylamino(thio)carbonyl compounds CBR3, CTH, CBR1 ALOX15 2292/4885TSHR 820/4885ALDH1A1 261/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.