Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | CCR2 | P41597 | 8/20 | 0.58 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7641409 | 0.85 | POLB (0.65) | POLBALDH1A1CCR2GPR139HTT | |
| SCHEMBL14528906 | 0.80 | GPR139 (0.66) | POLBALDH1A1CCR2GPR139HTT | |
| SCHEMBL14528425 | 0.80 | GPR139 (0.62) | POLBALDH1A1CCR2GPR139HTT | |
| SCHEMBL30407428 | 0.78 | POLB (0.67) | POLBALDH1A1CCR2GPR139HTT | |
| SCHEMBL613062 | 0.78 | POLB (0.67) | POLBALDH1A1CCR2GPR139HTT | |
| SCHEMBL7109292 | 0.78 | GPR139 (0.70) | POLBALDH1A1CCR2GPR139HTT | |
| SCHEMBL27970190 | 0.77 | POLB (0.74) | POLBALDH1A1HDAC3HDAC1TP53BP1 | |
| SCHEMBL17923260 | 0.77 | ALDH1A1 (0.51) | POLBALDH1A1HDAC3HDAC1TP53BP1 | |
| SCHEMBL23014295 | 0.76 | GPR139 (0.64) | POLBALDH1A1CCR2GPR139HTT | |
| SCHEMBL8947129 | 0.76 | POLB (0.68) | POLBALDH1A1CCR2GPR139HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1351924-A2 | DIAMINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | Bristol-Myers Squibb Pharma Company (US) | 2003-10-15 | — | — | EP | disclosed |
| WO-2002050019-A2 | DIAMINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | BRISTOL-MYERS SQUIBB PHARMA CO. (US) | 2002-06-27 | — | — | WO | disclosed |