Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
| ▸ | CCR2 | P41597 | 13/20 | 0.47 |
| ▸ | CCR5 | P51681 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | PLK1 | P53350 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30137413 | 0.81 | RXFP1 (0.59) | RXFP1CCR2LMNAPOLBCNR2 | |
| SCHEMBL25026713 | 0.81 | RXFP1 (0.59) | RXFP1CCR2LMNAPOLBCNR2 | |
| SCHEMBL7109818 | 0.79 | RXFP1 (0.51) | RXFP1CCR2LMNAMEN1TSHR | |
| SCHEMBL686427 | 0.79 | RXFP1 (0.58) | RXFP1CCR2LMNAPOLBPLK1 | |
| SCHEMBL7112858 | 0.78 | CCR2 (0.44) | CCR2 | |
| SCHEMBL1138788 | 0.78 | RXFP1 (0.57) | RXFP1CCR2LMNAPOLBCNR2 | |
| SCHEMBL7154000 | 0.77 | L3MBTL1 (0.42) | RXFP1CCR2CCR5LMNAPLK1 | |
| SCHEMBL7106212 | 0.77 | RXFP1 (0.55) | RXFP1CCR2LMNAPOLBCNR2 | |
| SCHEMBL14555701 | 0.77 | RXFP1 (0.56) | RXFP1CCR2LMNAPOLBCNR2 | |
| SCHEMBL2995691 | 0.76 | CCR2 (0.58) | RXFP1CCR2CCR5LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1351924-A2 | DIAMINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | Bristol-Myers Squibb Pharma Company (US) | 2003-10-15 | — | — | EP | claimed |
| WO-2002050019-A2 | DIAMINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | BRISTOL-MYERS SQUIBB PHARMA CO. (US) | 2002-06-27 | — | — | WO | claimed |