Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 5/20 | 0.67 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.65 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.65 |
| ▸ | DRD2 | P14416 | 4/20 | 0.60 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.60 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.60 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | HTR7 | P34969 | 1/20 | 0.58 |
| ▸ | DRD3 | P35462 | 3/20 | 0.53 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.53 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.53 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.53 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.53 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.53 |
| ▸ | DRD4 | P21917 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7041798 | 0.94 | GRIN1 (0.71) | HTR1AGRIN1GRIN2BDRD2ADRA1D | |
| Hydrochloric Acid SCHEMBL6867233 | 0.93 | GRIN1 (0.70) | HTR1AGRIN1GRIN2BDRD2ADRA1D | |
| SCHEMBL7661464 | 0.86 | DRD2 (0.61) | HTR1ADRD2ADRA1DADRA1AADRA1B | |
| Hydrochloric Acid SCHEMBL6868003 | 0.85 | DRD2 (0.60) | HTR1ADRD2ADRA1DADRA1AADRA1B | |
| SCHEMBL5178467 | 0.85 | ADRA1B (0.65) | HTR1AGRIN1GRIN2BDRD2ADRA1D | |
| SCHEMBL7667171 | 0.84 | HTR7 (0.53) | HTR1AGRIN1GRIN2BDRD2ADRA1D | |
| SCHEMBL5179345 | 0.84 | ADRA1B (0.60) | HTR1AGRIN1GRIN2BDRD2ADRA1D | |
| SCHEMBL7735999 | 0.83 | HTR1A (0.69) | HTR1ADRD2HTR7DRD3DRD4 | |
| Hydrochloric Acid SCHEMBL6866192 | 0.82 | HTR1A (0.68) | HTR1ADRD2ADRA1AHTR7DRD3 | |
| SCHEMBL7663973 | 0.80 | HTR7 (0.58) | HTR1ADRD2ADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1168714-C | Arylpiperazine derivatives useful as uroselective alpha-adrenoceptor blockers | ʵ | 2004-09-29 | — | — | CN | claimed |
| CN-1318052-A | Arylpiperazine derivatives useful as uroselective alpha-adrenoceptor blockers | RANBAXY LAB LTD (IN) | 2001-10-17 | — | — | CN | claimed |
| US-6812344-B1 | SYTHESIS OF COMPOUNDS FOR TREATMENT OF BENIGN PROSTATIC HYPERPLASIA | RANBAXY LABORATORIES LIMITED (IN) | 2004-11-02 | — | — | US | disclosed |
| CN-1168714-C | Arylpiperazine derivatives useful as uroselective alpha-adrenoceptor blockers | ʵ | 2004-09-29 | — | — | CN | disclosed |
| US-6420559-B1 | THE COMPOUNDS ARE USEFUL FOR TREATMENT OF DISEASE CONDITIONS, SUCH AS PERIPHERAL VASCULAR DISEASE, CONGESTIVE HEART FAILURE, HYPERTENSION AND ESPECIALLY BENIGN PROSTATIC HYPERTROPHY. | RANBAXY LABORATORIES LIMITED (IN) | 2002-07-16 | — | — | US | disclosed |
| US-6420366-B1 | PERIPHERAL VASCULAR DISEASE, CONGESTIVE HEART FAILURE, HYPERTENSION AND ESPECIALLY BENIGN PROSTATIC HYPERTROPHY. | RANBAXY LABORATORIES LIMITED (IN) | 2002-07-16 | — | — | US | disclosed |
| US-6410735-B1 | CONGESTIVE HEART FAILURE; HYPOTENSIVE AGENTS; BENGIN PROSTATIC HYPERPLASIA | RANBAXY LABORATORIES LIMITED (IN) | 2002-06-25 | — | — | US | disclosed |
| CN-1318052-A | Arylpiperazine derivatives useful as uroselective alpha-adrenoceptor blockers | RANBAXY LAB LTD (IN) | 2001-10-17 | — | — | CN | disclosed |
| EP-1097134-A1 | ARYLPIPERAZINE DERIVATIVES USEFUL AS UROSELECTIVE ALPHA1-ADRENOCEPTOR BLOCKERS | RANBAXY LABORATORIES, LTD. (IN) | 2001-05-09 | — | — | EP | disclosed |
| US-6090809-A | 1-(4-arylpiperazin-1-yl)-ω-[n-(α..omega.-dicarboximido)]-alkanes useful as uro-selective α1 -adrenoceptor blockers | RANBAXY LABORATORIES LIMITED (IN) | 2000-07-18 | — | — | US | disclosed |
| US-6083950-A | TREATMENT OF PERIPHERAL VASCULAR DISEASE, CONGESTIVE HEART FAILURE, HYPERTENSION AND ESPECIALLY BENIGN PROSTATIC HYPERTROPHY | RANBAXY LABORATORIES LIMITED (IN) | 2000-07-04 | — | — | US | disclosed |
| WO-2000005206-A1 | ARYLPIPERAZINE DERIVATIVES USEFUL AS URO-SELECTIVE ALPHA-1-ADRENOCEPTOR BLOCKERS | RANBAXY LABORATORIES LIMITED (US) | 2000-02-03 | — | — | WO | disclosed |
| WO-2000005205-A1 | ARYLPIPERAZINE DERIVATIVES USEFUL AS UROSELECTIVE ALPHA1-ADRENOCEPTOR BLOCKERS | RANBAXY LABORATORIES LIMITED (US) | 2000-02-03 | — | — | WO | disclosed |