Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 3/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 5/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | PPIA | P62937 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.51 |
| ▸ | CDK9 | P50750 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL712071 | 0.84 | MEN1 (0.58) | PKMMEN1KMT2AALDH1A1PPIA | |
| SCHEMBL712361 | 0.80 | ALDH1A1 (0.59) | PKMMEN1KMT2AALDH1A1PPIA | |
| SCHEMBL3129504 | 0.78 | MEN1 (0.64) | PKMMEN1KMT2AALDH1A1PPIA | |
| SCHEMBL711626 | 0.76 | ALDH1A1 (0.60) | PKMNPC1RAB9AMEN1KMT2A | |
| SCHEMBL713307 | 0.75 | DHODH (0.52) | NPC1HPGDRAB9AMEN1KMT2A | |
| SCHEMBL15508074 | 0.74 | PKM (1.00) | PKMMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL27716238 | 0.74 | DHODH (0.79) | PKMNPC1HPGDRAB9AMEN1 | |
| SCHEMBL8343595 | 0.74 | NPC1 (0.75) | NPC1HPGDRAB9AMEN1KMT2A | |
| SCHEMBL9230514 | 0.73 | PKM (0.90) | PKMHPGDMEN1KMT2AALDH1A1 | |
| SCHEMBL713887 | 0.73 | ILK (0.65) | PKMNPC1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8124610-B2 | Sodium channel inhibitors | ICAGEN INC. (US) | 2012-02-28 | — | — | US | claimed |
| EP-2173743-A2 | SODIUM CHANNEL INHIBITORS | Icagen, Inc. (US) | 2010-04-14 | — | — | EP | disclosed |
| WO-2009012242-A2 | SODIUM CHANNEL INHIBITORS | ICAGEN, INC. (US) | 2009-01-22 | — | — | WO | disclosed |