Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.60 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.59 |
| ▸ | FBP1 | P09467 | 3/20 | 0.55 |
| ▸ | VCP | P55072 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.51 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7110533 | 1.00 | NFE2L2 (0.60) | NFE2L2CYP19A1FBP1VCPALDH1A1 | |
| SCHEMBL7994558 | 1.00 | NFE2L2 (0.60) | NFE2L2CYP19A1FBP1VCPALDH1A1 | |
| SCHEMBL11020635 | 0.84 | MEN1 (0.53) | CYP19A1FBP1MAPTRAB9ANPC1 | |
| SCHEMBL11019081 | 0.84 | MEN1 (0.53) | CYP19A1FBP1MAPTRAB9ANPC1 | |
| SCHEMBL11023346 | 0.84 | MEN1 (0.53) | CYP19A1FBP1MAPTRAB9ANPC1 | |
| SCHEMBL15498134 | 0.81 | NFE2L2 (0.89) | NFE2L2CYP19A1FBP1VCPALDH1A1 | |
| SCHEMBL11020247 | 0.81 | KMT2A (0.60) | NFE2L2CYP19A1FBP1ALDH1A1MAPT | |
| SCHEMBL6798940 | 0.80 | NFE2L2 (0.70) | NFE2L2CYP19A1FBP1VCPALDH1A1 | |
| SCHEMBL6798937 | 0.80 | NFE2L2 (0.70) | NFE2L2CYP19A1FBP1VCPALDH1A1 | |
| SCHEMBL11301074 | 0.78 | CYP19A1 (0.93) | NFE2L2CYP19A1FBP1VCPALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030203908-A1 | Dihydrofolate reductase inhibitors | ISIS INNOVATION LIMITED (GB) | 2003-10-30 | — | — | US | disclosed |
| WO-2001053276-A1 | DIHYDROFOLATE REDUCTASE INHIBITORS | ISIS INNOVATION LIMITED (GB) | 2001-07-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030203908-A1 | Dihydrofolate reductase inhibitors | DHFR, CBR1, GRHPR | NFE2L2 1783/4885CYP19A1 163/4885FBP1 277/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.