Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 1/20 | 0.75 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.75 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.75 |
| ▸ | KMO | O15229 | 2/20 | 0.66 |
| ▸ | RXRA | P19793 | 2/20 | 0.58 |
| ▸ | RXRB | P28702 | 2/20 | 0.58 |
| ▸ | DHODH | Q02127 | 1/20 | 0.54 |
| ▸ | F2 | P00734 | 2/20 | 0.54 |
| ▸ | F10 | P00742 | 2/20 | 0.54 |
| ▸ | C1S | P09871 | 1/20 | 0.50 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.50 |
| ▸ | F12 | P00748 | 1/20 | 0.50 |
| ▸ | F7 | P08709 | 1/20 | 0.50 |
| ▸ | F3 | P13726 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL431391 | 0.90 | PRSS1 (0.59) | PRSS1PRSS2PRSS3F2F10 | |
| Ammonia Solution, Strong SCHEMBL5000059 | 0.88 | F2 (0.57) | PRSS1PRSS2PRSS3F2F10 | |
| Ammonia Solution, Strong SCHEMBL5000063 | 0.88 | F2 (0.57) | PRSS1PRSS2PRSS3F2F10 | |
| SCHEMBL14676446 | 0.86 | PRSS1 (1.00) | PRSS1PRSS2PRSS3KMOF2 | |
| Hydrochloric Acid SCHEMBL9792863 | 0.86 | PRSS1 (0.83) | PRSS1PRSS2PRSS3F2F10 | |
| SCHEMBL71238 | 0.85 | KMO (0.86) | KMORXRARXRBKEAP1LMNA | |
| SCHEMBL29904709 | 0.85 | KMO (0.86) | KMORXRARXRBKEAP1LMNA | |
| SCHEMBL30725957 | 0.85 | KMO (0.86) | KMORXRARXRBKEAP1LMNA | |
| SCHEMBL18397582 | 0.84 | KMO (0.70) | KMORXRARXRBDHODH | |
| Hydrochloric Acid SCHEMBL697893 | 0.84 | PRSS1 (0.96) | PRSS1PRSS2PRSS3KMOF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030135055-A1 | Aminosulfonylbiphenyl derivatives | MERCK PATENT GMBH (DE) | 2003-07-17 | — | — | US | claimed |
| US-20030135055-A1 | Aminosulfonylbiphenyl derivatives | MERCK PATENT GMBH (DE) | 2003-07-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030135055-A1 | Aminosulfonylbiphenyl derivatives | APOB, F12, SERPINB1 | PRSS1 34/4885PRSS2 129/4885PRSS3 156/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.