Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 11/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | BUB1 | O43683 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7118600 | 0.88 | JAK2 (0.40) | JAK2JAK1CNR2ALDH1A1 | |
| SCHEMBL7117133 | 0.86 | HDAC6 (0.35) | NAMPTMAP2K1BUB1 | |
| SCHEMBL7783692 | 0.84 | HDAC6 (0.37) | BUB1 | |
| SCHEMBL7463477 | 0.83 | ITGA1 (0.37) | CA2MAP2K1 | |
| SCHEMBL7123741 | 0.79 | NAMPT (0.38) | JAK2JAK1NAMPTMAP2K1BUB1 | |
| SCHEMBL7784132 | 0.78 | KMT2A (0.46) | NAMPTCA2MAP2K1SMN1; SMN2ALDH1A1 | |
| SCHEMBL7122822 | 0.77 | KMT2A (0.35) | MAP2K1LMNASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL7122977 | 0.77 | NAMPT (0.35) | JAK2JAK1NAMPTCA2MAP2K1 | |
| SCHEMBL7464207 | 0.77 | CCR6 (0.34) | MAP2K1SMN1; SMN2BUB1 | |
| SCHEMBL6264183 | 0.77 | MEN1 (0.49) | JAK2JAK1NAMPTCNR2MAP2K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2003504401-A | — | — | 2003-02-04 | — | — | JP | claimed |
| EP-1202724-A2 | METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2002-05-08 | — | — | EP | claimed |
| WO-2001005393-A2 | METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-01-25 | — | — | WO | claimed |